Method for detecting the presence of prostate cancer
Patent
·
OSTI ID:1176232
The present invention relates to compositions and methods for cancer diagnosis, treatment and drug screening. In particular, the present invention provides compositions and methods for targeting the nuclear translocation of IkB kinase-.alpha. (IKK.alpha.) and the IKK.alpha.-mediated suppression of Maspin expression observed in metastatic prostate cancer cells.
- Research Organization:
- Univ. of California, Oakland, CA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- FG03-86ER60429
- Assignee:
- The Regents of the University of California (Oakland, CA)
- Patent Number(s):
- 7,695,921
- Application Number:
- 12/004,696
- OSTI ID:
- 1176232
- Country of Publication:
- United States
- Language:
- English
IκB kinase-α acts in the epidermis to control skeletal and craniofacial morphogenesis
|
journal | April 2004 |
Maspin is up-regulated in premalignant prostate epithelia
|
journal | November 2002 |
Nuclear cytokine-activated IKKα controls prostate cancer metastasis by repressing Maspin
|
journal | March 2007 |
Upregulation of cyclooxygenase-2 is accompanied by increased expression of nuclear factor-κB and IκB kinase-α in human colorectal cancer epithelial cells
|
journal | May 2003 |
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