Biochemical and biophysical understanding of metal ion selectivity of DNAzymes

Hwang, Kevin; Hosseinzadeh, Parisa; Lu, Yi

doi:10.1016/j.ica.2016.04.017

Title: Biochemical and biophysical understanding of metal ion selectivity of DNAzymes

Journal Article · Sat Apr 23 00:00:00 EDT 2016 · Inorganica Chimica Acta

DOI:https://doi.org/10.1016/j.ica.2016.04.017· OSTI ID:1533834

Hwang, Kevin ^[1]; Hosseinzadeh, Parisa ^[1]; Lu, Yi ^[1]

Univ. of Illinois at Urbana-Champaign, IL (United States)

This review summarizes research on the metal-binding properties of catalytic DNAzymes, towards the goal of understanding the structural properties leading to metal ion specificity. Progress made and insight gained from a range of biochemical and biophysical techniques are covered, and promising directions for future investigations are discussed.

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Research Organization:: Univ. of Illinois at Urbana-Champaign, IL (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: FG02-08ER64568

OSTI ID:: 1533834

Alternate ID(s):: OSTI ID: 1359173

Journal Information:: Inorganica Chimica Acta, Vol. 452, Issue C; ISSN 0020-1693

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 72 works

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A Stereochemical Glimpse of the Active Site of the 8−17 Deoxyribozyme from Iodine-Mediated Cross-Links Formed with the Substrate’s Scissile Site Sekhon, Gurpreet S.; Sen, Dipankar Biochemistry, Vol. 49, Issue 42 https://doi.org/10.1021/bi1013547	journal	September 2010
Dissecting metal ion–dependent folding and catalysis of a single DNAzyme Kim, Hee-Kyung; Rasnik, Ivan; Liu, Juewen Nature Chemical Biology, Vol. 3, Issue 12 https://doi.org/10.1038/nchembio.2007.45	journal	October 2007
Rational evolution of Cd²⁺-specific DNAzymes with phosphorothioate modified cleavage junction and Cd²⁺sensing Huang, Po-Jung Jimmy; Liu, Juewen Nucleic Acids Research, Vol. 43, Issue 12 https://doi.org/10.1093/nar/gkv519	journal	May 2015
Chemiluminescence and Chemiluminescence Resonance Energy Transfer (CRET) Aptamer Sensors Using Catalytic Hemin/G-Quadruplexes Liu, Xiaoqing; Freeman, Ronit; Golub, Eyal ACS Nano, Vol. 5, Issue 9 https://doi.org/10.1021/nn202799d	journal	August 2011
FRET Study of a Trifluorophore-Labeled DNAzyme Liu, Juewen; Lu, Yi Journal of the American Chemical Society, Vol. 124, Issue 51 https://doi.org/10.1021/ja027647z	journal	December 2002
Ligating DNA with DNA Sreedhara, Alavattam; Li, Yingfu; Breaker, Ronald R. Journal of the American Chemical Society, Vol. 126, Issue 11 https://doi.org/10.1021/ja039713i	journal	March 2004
A crystallographic study of metal-binding to yeast phenylalanine transfer RNA Jack, A.; Landner, J. E.; Rhodes, D. Journal of Molecular Biology, Vol. 111, Issue 3 https://doi.org/10.1016/S0022-2836(77)80054-5	journal	April 1977
Ultrasensitive DNAzyme Beacon for Lanthanides and Metal Speciation Huang, Po-Jung Jimmy; Lin, Jenny; Cao, Jing Analytical Chemistry, Vol. 86, Issue 3 https://doi.org/10.1021/ac403762s	journal	January 2014

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Reselection Yielding a Smaller and More Active Silver-Specific DNAzyme Gu, Lide; Saran, Runjhun; Yan, Wanli ACS Omega, Vol. 3, Issue 11 https://doi.org/10.1021/acsomega.8b02039	journal	November 2018
Theranostic DNAzymes Zhou, Wenhu; Ding, Jinsong; Liu, Juewen Theranostics, Vol. 7, Issue 4 https://doi.org/10.7150/thno.17736	journal	January 2017

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