Treatment of small-cell lung cancer xenografts with iodine-313-anti-neural cell adhesion molecule monoclonal antibody and evaluation of absorbed dose in tissue

Journal Article · Tue Feb 01 04:00:00 EST 1994 · Journal of Nuclear Medicine Technology

OSTI ID:135836

Hosono, Makoto; Endo, Keigo; Hosono, Masako N ^[1]

---

1. Osaka City Univ. School of Medicine, (Japan); and others

Human small-cell lung cancer (SCLC) is considered a feasible target for immunotherapy using a radiolabeled monoclonal antibody (Mab). A murine Mab, NE150 (IgG1), reacts with the neural cell adhesion molecule, which is identical to cluster 1 antigen of SCLC. To estimate their therapeutic effects, NE150 and an isotype-matched control Mab were labeled with {sup 131}I and administered intravenously as a single dose into athymic mice inoculated with a NCI-H69 SCLC xenograft. The absorbed dose in organs was also examined based upon a long-term biodistribution study of {sup 131}I-NE150. Tumors initial volume 563.4 {plus_minus} 223.5 mm{sup 3} treated with 11.1 MBq (300 {mu}Ci) of {sup 131}I-NE150 diminished and became invisible at days 30-33, demonstrating a 60-day mean growth delay to reach a tripled initial volume compared with sham-treated tumors. Cumulative absorbed doses were estimated to be 2310, 410, 500, 330, and 790 cGy for the tumor, liver, kidney, spleen and lung, respectively. Iodine-131-NE150 had potent therapeutic effects against SCLC transplants in athymic mice, however, careful assessment of the side effects, improvement of radioiodination and chimerization of the Mab might be necessary to achieve efficient targeting in clinical therapeutic applications. 25 refs., 2 figs., 3 tabs.

• OSTI ID: 135836
• Journal Information: Journal of Nuclear Medicine Technology, Journal Name: Journal of Nuclear Medicine Technology Journal Issue: 2 Vol. 35; ISSN JNMTB4; ISSN 0091-4916
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
56 BIOLOGY AND MEDICINE
APPLIED STUDIES
IODINE 131
LUNGS
NEOPLASMS
RADIATION DOSES
RADIOIMMUNOTHERAPY
RADIOPHARMACEUTICALS
TISSUE DISTRIBUTION