Emerging structural insights into the function of ionotropic glutamate receptors

Karakas, Erkan; Regan, Michael C.; Furukawa, Hiro

doi:10.1016/j.tibs.2015.04.002

Emerging structural insights into the function of ionotropic glutamate receptors

Journal Article · Fri May 01 04:00:00 EDT 2015 · Trends in Biochemical Sciences

DOI:https://doi.org/10.1016/j.tibs.2015.04.002· OSTI ID:1352280

Karakas, Erkan ^[1]; Regan, Michael C. ^[1]; Furukawa, Hiro ^[1]

Cold Spring Harbor Laboratory Cold Spring Harbor, NY (United States)

Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that mediate excitatory neurotransmission crucial for brain development and function, including learning and memory formation. Recently a wealth of structural studies on iGluRs including AMPA receptors (AMPARs), kainate receptors, and NMDA receptors (NMDARs) became available. These studies showed structures of non-NMDARs including AMPAR and kainate receptor in various functional states, thereby providing the first visual sense of how non-NMDAR iGluRs may function in the context of homotetramers. Furthermore, they provided the first view of heterotetrameric NMDAR ion channels, and this illuminated the similarities with and differences from non-NMDARs, thus raising a mechanistic distinction between the two groups of iGluRs. We review mechanistic insights into iGluR functions gained through structural studies of multiple groups.

View Accepted Manuscript (DOE)

Research Organization:: Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)

Sponsoring Organization:: National Institutes of Health (NIH); USDOE

OSTI ID:: 1352280

Journal Information:: Trends in Biochemical Sciences, Journal Name: Trends in Biochemical Sciences Journal Issue: 6 Vol. 40; ISSN 0968-0004

Publisher:: Cell PressCopyright Statement

Country of Publication:: United States

Language:: ENGLISH

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