Molecular Mechanisms of Innate Immune Inhibition by Non-Segmented Negative-Sense RNA Viruses

Chatterjee, Srirupa; Basler, Christopher F.; Amarasinghe, Gaya K.; Leung, Daisy W.

doi:10.1016/j.jmb.2016.07.017

Molecular Mechanisms of Innate Immune Inhibition by Non-Segmented Negative-Sense RNA Viruses

Journal Article · Sun Jul 31 00:00:00 EDT 2016 · Journal of Molecular Biology

DOI:https://doi.org/10.1016/j.jmb.2016.07.017· OSTI ID:1351396

Chatterjee, Srirupa ^[1]; Basler, Christopher F. ^[2]; Amarasinghe, Gaya K. ^[1]; Leung, Daisy W. ^[1]

Washington Univ. School of Medicine, St. Louis, MO (United States)
Georgia State Univ., Atlanta, GA (United States)

The host innate immune system serves as the first line of defense against viral infections. Germline-encoded pattern recognition receptors detect molecular patterns associated with pathogens and activate innate immune responses. Of particular relevance to viral infections are those pattern recognition receptors that activate type I interferon responses, which establish an antiviral state. The order Mononegavirales is composed of viruses that possess single-stranded, non-segmented negative-sense (NNS) RNA genomes and are important human pathogens that consistently antagonize signaling related to type I interferon responses. NNS viruses have limited encoding capacity compared to many DNA viruses, and as a likely consequence, most open reading frames encode multifunctional viral proteins that interact with host factors in order to evade host cell defenses while promoting viral replication. In this review, we will discuss the molecular mechanisms of innate immune evasion by select NNS viruses. Furthermore, a greater understanding of these interactions will be critical in facilitating the development of effective therapeutics and viral countermeasures.

View Accepted Manuscript (DOE)

Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States)

Sponsoring Organization:: American Heart Association; Dept. of Defense, Defense Threat Reduction Agency; NIH

OSTI ID:: 1351396

Journal Information:: Journal of Molecular Biology, Journal Name: Journal of Molecular Biology Journal Issue: 17 Vol. 428; ISSN 0022-2836

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: ENGLISH

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