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Title: Filovirus pathogenesis and immune evasion: insights from Ebola virus and Marburg virus

Abstract

Ebola viruses and Marburg viruses, members of the filovirus family, are zoonotic pathogens that cause severe disease in people, as highlighted by the latest Ebola virus epidemic in West Africa. Filovirus disease is characterized by uncontrolled virus replication and the activation of host responses that contribute to pathogenesis. Underlying these phenomena is the potent suppression of host innate antiviral responses, particularly the type I interferon response, by viral proteins, which allows high levels of viral replication. Here, in this Review, we describe the mechanisms used by filoviruses to block host innate immunity and discuss the links between immune evasion and filovirus pathogenesis.

Authors:
 [1];  [2];  [3]
  1. Univ. of California, Riverside, CA (United States)
  2. Washington Univ., St. Louis, MO (United States)
  3. Icahn School of Medicine at Mount Sinai, New York, NY (United States)
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org.:
U.S. Department of Defense and the Defense Threat Reduction Agency; National Institutes of Health (NIH)
OSTI Identifier:
1351402
Grant/Contract Number:  
U19 AI109945; R01 AI059536; U19 AI109664; U19 AI070489; R01 AI081914; HDTRA1-12-1-0051; HDTRA1-14-1-0013
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
Nature Reviews Microbiology
Additional Journal Information:
Journal Volume: 13; Journal Issue: 11; Journal ID: ISSN 1740-1526
Publisher:
Springer Nature
Country of Publication:
United States
Language:
ENGLISH
Subject:
60 APPLIED LIFE SCIENCES; Ebola virus; Marburg virus; Viral immune evasion; Viral pathogenesis; Virus-host interactions; Virus structures

Citation Formats

Messaoudi, Ilhem, Amarasinghe, Gaya K., and Basler, Christopher F. Filovirus pathogenesis and immune evasion: insights from Ebola virus and Marburg virus. United States: N. p., 2015. Web. doi:10.1038/nrmicro3524.
Messaoudi, Ilhem, Amarasinghe, Gaya K., & Basler, Christopher F. Filovirus pathogenesis and immune evasion: insights from Ebola virus and Marburg virus. United States. doi:10.1038/nrmicro3524.
Messaoudi, Ilhem, Amarasinghe, Gaya K., and Basler, Christopher F. Tue . "Filovirus pathogenesis and immune evasion: insights from Ebola virus and Marburg virus". United States. doi:10.1038/nrmicro3524. https://www.osti.gov/servlets/purl/1351402.
@article{osti_1351402,
title = {Filovirus pathogenesis and immune evasion: insights from Ebola virus and Marburg virus},
author = {Messaoudi, Ilhem and Amarasinghe, Gaya K. and Basler, Christopher F.},
abstractNote = {Ebola viruses and Marburg viruses, members of the filovirus family, are zoonotic pathogens that cause severe disease in people, as highlighted by the latest Ebola virus epidemic in West Africa. Filovirus disease is characterized by uncontrolled virus replication and the activation of host responses that contribute to pathogenesis. Underlying these phenomena is the potent suppression of host innate antiviral responses, particularly the type I interferon response, by viral proteins, which allows high levels of viral replication. Here, in this Review, we describe the mechanisms used by filoviruses to block host innate immunity and discuss the links between immune evasion and filovirus pathogenesis.},
doi = {10.1038/nrmicro3524},
journal = {Nature Reviews Microbiology},
issn = {1740-1526},
number = 11,
volume = 13,
place = {United States},
year = {2015},
month = {10}
}

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Free Publicly Available Full Text
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Cited by: 93 works
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