Analysis of apoB gene polymorphism in control sample and group of patients with coronary heart disease from Moscow
- Center for Preventive Medicine, Moscow (Russian Federation); and others
We have analyzed two polymorphic regions of the apo B gene (5{prime} (CA)n microsatellite and insertion/deletion polymorphisms) in a random control sample and coronary heart disease (CHD) patients from Moscow. For this purpose we have used PCR technique followed by high-resolution PAGE. In the control sample only 3 different allelic variants of the 5{prime} minisatellite existed with 14 (frequency 70,7%), 15 (26,8%) and 16 (2.5%) CA repeats. In the patient`s group, allelic variants were also found with 13 CA repeats, but the frequency was very low (2.5%). However, we did not reveal any significant differences in allele and genotype distributions of insertion/deletion polymorphisms in the control group and the group of CHD patients (insertion frequency 67.9% and 62.5%, respectively).
- OSTI ID:
- 134668
- Report Number(s):
- CONF-941009--
- Journal Information:
- American Journal of Human Genetics, Journal Name: American Journal of Human Genetics Journal Issue: Suppl.3 Vol. 55; ISSN AJHGAG; ISSN 0002-9297
- Country of Publication:
- United States
- Language:
- English
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