The Univ. of New Mexico, Albuquerque, NM (United States); The Mind Research Network, Albuquerque, NM (United States); The Univ. of New Mexico School of Medicine, Albuquerque, NM (United States); Office of Scientific and Technical Information (OSTI)
The Univ. of New Mexico, Albuquerque, NM (United States); The Mind Research Network, Albuquerque, NM (United States)
The Mind Research Network, Albuquerque, NM (United States)
The Mind Research Network, Albuquerque, NM (United States); The Univ. of New Mexico School of Medicine, Albuquerque, NM (United States); The Univ. of New Mexico, Albuquerque, NM (United States)
Transcranial direct current stimulation (tDCS) modulates glutamatergic neurotransmission and can be utilized as a novel treatment intervention for a multitude of populations. However, the exact mechanism by which tDCS modulates the brain's neural architecture, from the micro to macro scales, have yet to be investigated. In this paper, using a within-subjects design, resting-state functional magnetic resonance imaging (rs-fMRI) and proton magnetic resonance spectroscopy (1H MRS) were performed immediately before and after the administration of anodal tDCS over right parietal cortex. Group independent component analysis (ICA) was used to decompose fMRI scans into 75 brain networks, from which 12 resting-state networks were identified that had significant voxel-wise functional connectivity to anatomical regions of interest. 1H MRS was used to obtain estimates of combined glutamate and glutamine (Glx) concentrations from bilateral intraparietal sulcus. Paired sample t-tests showed significantly increased Glx under the anodal electrode, but not in homologous regions of the contralateral hemisphere. Increases of within-network connectivity were observed within the superior parietal, inferior parietal, left frontal–parietal, salience and cerebellar intrinsic networks, and decreases in connectivity were observed in the anterior cingulate and the basal ganglia (p<0.05, FDR-corrected). Individual differences in Glx concentrations predicted network connectivity in most of these networks. Finally, the observed relationships between glutamatergic neurotransmission and network connectivity may be used to guide future tDCS protocols that aim to target and alter neuroplastic mechanisms in healthy individuals as well as those with psychiatric and neurologic disorders.
Hunter, Michael A., et al. "Baseline effects of transcranial direct current stimulation on glutamatergic neurotransmission and large-scale network connectivity." Brain Research, vol. 1594, Oct. 2014. https://doi.org/10.1016/j.brainres.2014.09.066
Hunter, Michael A., Coffman, Brian A., Gasparovic, Charles, Calhoun, Vince D., Trumbo, Michael C., & Clark, Vincent P. (2014). Baseline effects of transcranial direct current stimulation on glutamatergic neurotransmission and large-scale network connectivity. Brain Research, 1594. https://doi.org/10.1016/j.brainres.2014.09.066
Hunter, Michael A., Coffman, Brian A., Gasparovic, Charles, et al., "Baseline effects of transcranial direct current stimulation on glutamatergic neurotransmission and large-scale network connectivity," Brain Research 1594 (2014), https://doi.org/10.1016/j.brainres.2014.09.066
@article{osti_1344389,
author = {Hunter, Michael A. and Coffman, Brian A. and Gasparovic, Charles and Calhoun, Vince D. and Trumbo, Michael C. and Clark, Vincent P.},
title = {Baseline effects of transcranial direct current stimulation on glutamatergic neurotransmission and large-scale network connectivity},
annote = {Transcranial direct current stimulation (tDCS) modulates glutamatergic neurotransmission and can be utilized as a novel treatment intervention for a multitude of populations. However, the exact mechanism by which tDCS modulates the brain's neural architecture, from the micro to macro scales, have yet to be investigated. In this paper, using a within-subjects design, resting-state functional magnetic resonance imaging (rs-fMRI) and proton magnetic resonance spectroscopy (1H MRS) were performed immediately before and after the administration of anodal tDCS over right parietal cortex. Group independent component analysis (ICA) was used to decompose fMRI scans into 75 brain networks, from which 12 resting-state networks were identified that had significant voxel-wise functional connectivity to anatomical regions of interest. 1H MRS was used to obtain estimates of combined glutamate and glutamine (Glx) concentrations from bilateral intraparietal sulcus. Paired sample t-tests showed significantly increased Glx under the anodal electrode, but not in homologous regions of the contralateral hemisphere. Increases of within-network connectivity were observed within the superior parietal, inferior parietal, left frontal–parietal, salience and cerebellar intrinsic networks, and decreases in connectivity were observed in the anterior cingulate and the basal ganglia (p<0.05, FDR-corrected). Individual differences in Glx concentrations predicted network connectivity in most of these networks. Finally, the observed relationships between glutamatergic neurotransmission and network connectivity may be used to guide future tDCS protocols that aim to target and alter neuroplastic mechanisms in healthy individuals as well as those with psychiatric and neurologic disorders.},
doi = {10.1016/j.brainres.2014.09.066},
url = {https://www.osti.gov/biblio/1344389},
journal = {Brain Research},
issn = {ISSN 0006-8993},
volume = {1594},
place = {United States},
publisher = {Elsevier},
year = {2014},
month = {10}}