Global functional connectivity density alterations in patients with bipolar disorder with auditory verbal hallucinations and modest short‐term effects of transcranial direct current stimulation augmentation treatment—Baseline and follow‐up study

Zhuo, Chuanjun; Ji, Feng; Lin, Xiaodong; Tian, Hongjun; Wang, Lina; Xu, Yong; Wang, Wenqiang; Jiang, Deguo

doi:10.1002/brb3.1637

Global functional connectivity density alterations in patients with bipolar disorder with auditory verbal hallucinations and modest short‐term effects of transcranial direct current stimulation augmentation treatment—Baseline and follow‐up study

Journal Article · Sat Apr 18 00:00:00 EDT 2020 · Brain and Behavior (Online)

DOI:https://doi.org/10.1002/brb3.1637· OSTI ID:1615387

^[1]; Ji, Feng ^[2]; Lin, Xiaodong ^[3]; Tian, Hongjun ^[4]; Wang, Lina ^[4]; Xu, Yong ^[5]; Wang, Wenqiang ^[6]; Jiang, Deguo ^[3]

School of Mental Health Jining Medical University Jining China; Psychiatric‐Neuroimaging‐Genetics Laboratory Wenzhou Seventh People's Hospital Wenzhou China; Psychiatric‐Neuroimaging‐Genetics‐Comorbidity Laboratory Tianjin Mental Health Centre Tianjin Anding Hospital Mental Health Teaching Hospital of Tianjin Medical University Tianjin China; Department of Psychiatry First Hospital/First Clinical Medical College of Shanxi Medical University Taiyuan China; MDT Center for Cognitive Impairment and Sleep Disorders First Hospital of Shanxi Medical University Taiyuan China
School of Mental Health Jining Medical University Jining China
Psychiatric‐Neuroimaging‐Genetics Laboratory Wenzhou Seventh People's Hospital Wenzhou China
Psychiatric‐Neuroimaging‐Genetics‐Comorbidity Laboratory Tianjin Mental Health Centre Tianjin Anding Hospital Mental Health Teaching Hospital of Tianjin Medical University Tianjin China
Department of Psychiatry First Hospital/First Clinical Medical College of Shanxi Medical University Taiyuan China, MDT Center for Cognitive Impairment and Sleep Disorders First Hospital of Shanxi Medical University Taiyuan China
Co‐collaboration Laboratory of China and Canada Xiamen Xianyue Hospital and University of Alberta Xiamen China

Abstract Objectives

To investigate the neuroimaging characteristics of auditory verbal hallucinations (AVHs) in patients with bipolar disorder (BP) experiencing depressive episodes with and without AVHs, and alterations in those characteristics after transcranial direct current stimulation (tDCS).

Methods

For a baseline pilot study, we recruited 80 patients with BP and depressive status (40 with and 40 without AVHs), and 40 healthy controls (HCs). Their global functional connectivity density (gFCD) was screened by functional magnetic resonance imaging (fMRI). Voxel‐wise one‐way analysis of covariance (ANCOVA) was conducted to detect intergroup differences in gFCD. In a follow‐up study, the effects of 5 weeks of tDCS augmentation treatment on clinical symptoms and gFCD were assessed in the 40 BP patients with AVHs.

Results

Compared to HCs, BP patients with and without AVHs exhibited increased gFCD in the central parietal lobe, insular lobe, and middle cingulate cortex, with decreased gFCD in the posterior parietal cortex, lateral prefrontal cortex, and occipital lobe (all bilateral). Only patients with AVHs showed increased gFCD in the Broca and Wernicke regions, and decreased gFCD in the hippocampus (all bilateral). After 5 weeks of tDCS, AVHs were slightly alleviated and gFCD abnormalities in the hippocampus were mildly attenuated.

Conclusions

Patients with BP and AVHs showed disturbances in the brain's communication capacity mainly in the left frontoparietal network, control network, and memory circuitry. Five weeks of tDCS alleviated AVHs slightly, without improving depressive symptoms, and attenuated hippocampal gFCD alterations in these patients.

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Sponsoring Organization:: USDOE

OSTI ID:: 1615387

Alternate ID(s):: OSTI ID: 1615388

Journal Information:: Brain and Behavior (Online), Journal Name: Brain and Behavior (Online) Journal Issue: 6 Vol. 10; ISSN 2162-3279

Publisher:: Wiley Blackwell (John Wiley & Sons)Copyright Statement

Country of Publication:: United States

Language:: English

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