Precision mapping of multiple quantitative trait loci in humans

Journal Article · Thu Sep 01 04:00:00 EDT 1994 · American Journal of Human Genetics

OSTI ID:133901

Guo, S W ^[1]

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1. Univ. of Michigan, Ann Arbor, MI (United States)

Mapping complex quantitative traits in humans is in general a difficult task. Parametric methods are very efficient in mapping a single major quantitative trait locus but they are sensitive to violations in modeling assumptions such non-normality, absence of major genes, and biased sampling. Semi-parametric methods such as Haseman-Elston sib-pair method are more robust but they are less efficient than parametric ones. We have extended the sib-pair method to (1) incorporate information from multiple markers based on the gene identical-by-descent proportions and the proportion of allele sharing at the trait locus, all based on flanking markers; (2) to include sibship data; and (3) to allow for precise localization of multiple quantitative trait loci. We show through simulation that the power of the proposed approach is greater than the sib-pair method. Further extension to include other types of relative pairs is possible.

• OSTI ID: 133901
• Report Number(s): CONF-941009--
• Journal Information: American Journal of Human Genetics, Journal Name: American Journal of Human Genetics Journal Issue: Suppl.3 Vol. 55; ISSN AJHGAG; ISSN 0002-9297
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
99 GENERAL AND MISCELLANEOUS
BIOLOGICAL MARKERS
COMPUTERIZED SIMULATION
EFFICIENCY
GENES
GENETIC MAPPING
GENETICS
HUMAN CHROMOSOMES
HUMAN POPULATIONS
PHENOTYPE
RESOLUTION
STATISTICAL MODELS