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Title: Biological Bases for Radiation Adaptive Responses in the Lung

Abstract

Our main research objective was to determine the biological bases for low-dose, radiation-induced adaptive responses in the lung, and use the knowledge gained to produce an improved risk model for radiation-induced lung cancer that accounts for activated natural protection, genetic influences, and the role of epigenetic regulation (epiregulation). Currently, low-dose radiation risk assessment is based on the linear-no-threshold hypothesis, which now is known to be unsupported by a large volume of data.

Authors:
 [1];  [1];  [1];  [1]
  1. Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM (United States)
Publication Date:
Research Org.:
Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23)
OSTI Identifier:
1336929
Report Number(s):
DOE-SC0001173
DOE Contract Number:
SC0001173
Resource Type:
Technical Report
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ADAPTIVE SYSTEMS; RADIATION PROTECTION; LUNGS; NEOPLASMS; RISK ASSESSMENT; HYPOTHESIS; LOW DOSE IRRADIATION

Citation Formats

Scott, Bobby R., Lin, Yong, Wilder, Julie, and Belinsky, Steven. Biological Bases for Radiation Adaptive Responses in the Lung. United States: N. p., 2015. Web. doi:10.2172/1336929.
Scott, Bobby R., Lin, Yong, Wilder, Julie, & Belinsky, Steven. Biological Bases for Radiation Adaptive Responses in the Lung. United States. doi:10.2172/1336929.
Scott, Bobby R., Lin, Yong, Wilder, Julie, and Belinsky, Steven. Sun . "Biological Bases for Radiation Adaptive Responses in the Lung". United States. doi:10.2172/1336929. https://www.osti.gov/servlets/purl/1336929.
@article{osti_1336929,
title = {Biological Bases for Radiation Adaptive Responses in the Lung},
author = {Scott, Bobby R. and Lin, Yong and Wilder, Julie and Belinsky, Steven},
abstractNote = {Our main research objective was to determine the biological bases for low-dose, radiation-induced adaptive responses in the lung, and use the knowledge gained to produce an improved risk model for radiation-induced lung cancer that accounts for activated natural protection, genetic influences, and the role of epigenetic regulation (epiregulation). Currently, low-dose radiation risk assessment is based on the linear-no-threshold hypothesis, which now is known to be unsupported by a large volume of data.},
doi = {10.2172/1336929},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Sun Mar 01 00:00:00 EST 2015},
month = {Sun Mar 01 00:00:00 EST 2015}
}

Technical Report:

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