Biological Bases for Radiation Adaptive Responses in the Lung
- Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM (United States)
Our main research objective was to determine the biological bases for low-dose, radiation-induced adaptive responses in the lung, and use the knowledge gained to produce an improved risk model for radiation-induced lung cancer that accounts for activated natural protection, genetic influences, and the role of epigenetic regulation (epiregulation). Currently, low-dose radiation risk assessment is based on the linear-no-threshold hypothesis, which now is known to be unsupported by a large volume of data.
- Research Organization:
- Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM (United States)
- Sponsoring Organization:
- USDOE Office of Science (SC), Biological and Environmental Research (BER)
- DOE Contract Number:
- SC0001173
- OSTI ID:
- 1336929
- Report Number(s):
- DOE-SC0001173
- Country of Publication:
- United States
- Language:
- English
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