skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Supercomputer Simulations Help Develop New Approach to Fight Antibiotic Resistance

Abstract

ORNL leveraged powerful supercomputing to support research led by University of Oklahoma scientists to identify chemicals that seek out and disrupt bacterial proteins called efflux pumps, known to be a major cause of antibiotic resistance. By running simulations on Titan, the team selected molecules most likely to target and potentially disable the assembly of efflux pumps found in E. coli bacteria cells.

Authors:
;
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1332726
Resource Type:
Multimedia
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION; 59 BASIC BIOLOGICAL SCIENCES; ANTIBIOTIC RESISTANCE; BACTERIAL PROTEINS; FUNGI; VIRUSES; EFFLUX PUMPS; SUPERCOMPUTERS

Citation Formats

Zgurskaya, Helen, and Smith, Jeremy. Supercomputer Simulations Help Develop New Approach to Fight Antibiotic Resistance. United States: N. p., 2016. Web.
Zgurskaya, Helen, & Smith, Jeremy. Supercomputer Simulations Help Develop New Approach to Fight Antibiotic Resistance. United States.
Zgurskaya, Helen, and Smith, Jeremy. Thu . "Supercomputer Simulations Help Develop New Approach to Fight Antibiotic Resistance". United States. https://www.osti.gov/servlets/purl/1332726.
@article{osti_1332726,
title = {Supercomputer Simulations Help Develop New Approach to Fight Antibiotic Resistance},
author = {Zgurskaya, Helen and Smith, Jeremy},
abstractNote = {ORNL leveraged powerful supercomputing to support research led by University of Oklahoma scientists to identify chemicals that seek out and disrupt bacterial proteins called efflux pumps, known to be a major cause of antibiotic resistance. By running simulations on Titan, the team selected molecules most likely to target and potentially disable the assembly of efflux pumps found in E. coli bacteria cells.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2016},
month = {11}
}