Compositions and methods for increased ethanol titer from biomass

Jessen, Holly J.; Yi, Jian

Title: Compositions and methods for increased ethanol titer from biomass

Patent · Tue Nov 15 00:00:00 EST 2016

OSTI ID:1332276

Jessen, Holly J.; Yi, Jian

The present application discloses the identification of novel I. orientalis ADH1, ADHa, and ADHb genes, and the production and characterization of genetically modified yeast cells in which these genes were altered. Provided herein are isolated I. orientalis ADH1, ADHa, and ADHb polynucleotides and polypeptides, genetically modified yeast cells that overexpress I. orientalis ADH1 and/or contain deletions or disruptions of ADHa and/or ADHb, and methods of using culturing these modified cells to produce ethanol.

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Research Organization:: Cargill, Incorporated, Wayzata, MN (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: FC36-07GO17055

Assignee:: Cargill, Incorporated (Wayzata, MN)

Patent Number(s):: 9,493,793

Application Number:: 13/988,899

OSTI ID:: 1332276

Resource Relation:: Patent File Date: 2011 Nov 22

Country of Publication:: United States

Language:: English

References (19)

Compositions and methods for 3-hydroxypropionic acid production Jessen, Holly Jean; Rush, Brian J.; Huryta, Jeanette https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/9090918 US Patent Document 9,090,918	patent	July 2015
Biotransformation Using Genetically Modified Candida Ness, Jon E.; Minshull, Jeremy https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20100291653 US Patent Application 12/775306; 20100291653	patent-application	November 2010
Characterization of alcohol dehydrogenase 1 of the thermotolerant methylotrophic yeast Hansenula polymorpha Suwannarangsee, Surisa; Oh, Doo-Byoung; Seo, Jeong-Woo Applied Microbiology and Biotechnology, Vol. 88, Issue 2 https://doi.org/10.1007/s00253-010-2752-7	journal	July 2010
Alcohol dehydrogenases that catalyse methyl formate synthesis participate in formaldehyde detoxification in the methylotrophic yeastCandida boidinii Yurimoto, Hiroya; Lee, Bumjun; Yasuda, Fumi Yeast, Vol. 21, Issue 4 https://doi.org/10.1002/yea.1101	journal	March 2004
Overexpression of ADH1 confers hyper-resistance to formaldehyde in Saccharomyces cerevisiae Grey, Martin; Schmidt, Martin; Brendel, M. Current Genetics, Vol. 29, Issue 5 https://doi.org/10.1007/s002940050068	journal	April 1996
Evolution of a glucose-regulated ADH gene in the genus Saccharomyces Young, Elton T.; Sloan, James; Miller, Brady Gene, Vol. 245, Issue 2, p. 299-309 https://doi.org/10.1016/S0378-1119(00)00035-4	journal	March 2000
Resurrecting ancestral alcohol dehydrogenases from yeast Thomson, J. Michael; Gaucher, Eric A.; Burgan, Michelle F. Nature Genetics, Vol. 37, Issue 6 https://doi.org/10.1038/ng1553	journal	May 2005
Overexpression of ADH1 and HXT1 genes in the yeast Saccharomyces cerevisiae improves the fermentative efficiency during tequila elaboration Gutiérrez-Lomelí, Melesio; Torres-Guzmán, Juan Carlos; González-Hernández, Gloria Angélica Antonie van Leeuwenhoek, Vol. 93, Issue 4 https://doi.org/10.1007/s10482-007-9213-z	journal	February 2008
The Alcohol Dehydrogenase System in the Xylose-Fermenting Yeast Candida maltosa Lin, Yuping; He, Peng; Wang, Qinhong PLoS ONE, Vol. 5, Issue 7 https://doi.org/10.1371/journal.pone.0011752	journal	July 2010
The alcohol dehydrogenases of Saccharomyces cerevisiae: a comprehensive review de Smidt, Olga; du Preez, James C.; Albertyn, Jacobus FEMS Yeast Research, Vol. 8, Issue 7, p. 967-978 https://doi.org/10.1111/j.1567-1364.2008.00387.x	journal	November 2008
Effects of ADH2 Overexpression in Saccharomyces bayanus during Alcoholic Fermentation Maestre, O.; Garcia-Martinez, T.; Peinado, R. A. Applied and Environmental Microbiology, Vol. 74, Issue 3 https://doi.org/10.1128/AEM.01805-07	journal	December 2007
Enhanced ethanol production from sugarcane juice by galactose adaptation of a newly isolated thermotolerant strain of Pichia kudriavzevii Dhaliwal, Sandeep Singh; Oberoi, Harinder Singh; Sandhu, Simranjeet Kaur Bioresource Technology, Vol. 102, Issue 10, p. 5968-5975 https://doi.org/10.1016/j.biortech.2011.02.015	journal	May 2011
Isolation and Identification of a Novel Yeast Fermenting Ethanol under Acidic Conditions Hisamatsu, Makoto; Furubayashi, Takuya; Karita, Shuichi Journal of Applied Glycoscience, Vol. 53, Issue 2 https://doi.org/10.5458/jag.53.111	journal	January 2006
Automated Yeast Transformation Protocol to Engineer Saccharomyces cerevisiae Strains for Cellulosic Ethanol Production with Open Reading Frames That Express Proteins Binding to Xylose Isomerase Identified Using a Robotic Two-Hybrid Screen Hughes, Stephen R.; Rich, Joseph O.; Bischoff, Kenneth M. Journal of the Association for Laboratory Automation, Vol. 14, Issue 4, p. 200-212 https://doi.org/10.1016/j.jala.2009.02.006	journal	August 2009
Effect of lignocellulosic inhibitory compounds on growth and ethanol fermentation of newly-isolated thermotolerant Issatchenkia orientalis Kwon, Yong-Jin; Ma, An-Zhou; Li, Qian Bioresource Technology, Vol. 102, Issue 17, p. 8099-8104 https://doi.org/10.1016/j.biortech.2011.06.035	journal	September 2011
Candida krusei produces ethanol without production of succinic acid; a potential advantage for ethanol recovery by pervaporation membrane separation Nakayama, Shunichi; Morita, Tomotake; Negishi, Hideyuki FEMS Yeast Research, Vol. 8, Issue 5 https://doi.org/10.1111/j.1567-1364.2008.00384.x	journal	August 2008
Ethanol production from Kinnow mandarin (Citrus reticulata) peels via simultaneous saccharification and fermentation using crude enzyme produced by Aspergillus oryzae and the thermotolerant Pichia kudriavzevii strain Kaur Sandhu, Simanjeet; Singh Oberoi, Harinder; Singh Dhaliwal, Sandeep Annals of Microbiology, Vol. 62, Issue 2 https://doi.org/10.1007/s13213-011-0302-x	journal	July 2011
Study on Ethanol Fermentation Using D-Glucose Rich Fractions Obtained from Lignocelluloses by a Two-step Extraction with Sulfuric Acid and Issatchenkia orientalis MF 121 Thalagala, T. A. T. P.; Kodama, Shotaro; Mishima, Takashi Journal of Applied Glycoscience, Vol. 56, Issue 1 https://doi.org/10.5458/jag.56.7	journal	January 2009
Gene cloning, expression, and characterization of a novel acetaldehyde dehydrogenase from Issatchenkia terricola strain XJ-2 Yao, Zhengying; Zhang, Chong; Lu, Fengxia Applied Microbiology and Biotechnology, Vol. 93, Issue 5 https://doi.org/10.1007/s00253-011-3541-7	journal	August 2011

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