Coordinated multidisciplinary research program on carbon monoxide health effects. Final report
The objective of this project was to determine the subclinical effects of carbon monoxide (CO) on individuals with ischemic heart disease. Studies were conducted to improve procedures for measuring carboxyhemoglobin (COHb), and to characterize responses in Co-sensitive subjects. Eighteen subjects were exposed to 50 or 100 ppm CO to raise COHb levels to 3%. Times to onset of angina and significant ST segment depression were measured. Time to onset of angina was reduced by 100 ppm CO, but not by 50 ppm CO. Exposure to CO reduced the time to onset of angina by 5% at sea level and by 9% at high altitude. While the number of subjects tested was too small to conclusively assess the potential health risks of high altitude CO exposure, the results demonstrates the potential for significant health risks.
- Research Organization:
- California Univ., Irvine, CA (United States)
- OSTI ID:
- 128172
- Report Number(s):
- PB--95-270690/XAB; CNN: Contract ARB-A6-203-33
- Country of Publication:
- United States
- Language:
- English
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