Validation of GC and HPLC systems for residue studies
- Horizon Labs., Inc., Columbia, MO (United States)
For residue studies, GC and HPLC system performance must be validated prior to and during use. One excellent measure of system performance is the standard curve and associated chromatograms used to construct that curve. The standard curve is a model of system response to an analyte over a specific time period, and is prima facia evidence of system performance beginning at the auto sampler and proceeding through the injector, column, detector, electronics, data-capture device, and printer/plotter. This tool measures the performance of the entire chromatographic system; its power negates most of the benefits associated with costly and time-consuming validation of individual system components. Other measures of instrument and method validation will be discussed, including quality control charts and experimental designs for method validation.
- OSTI ID:
- 126059
- Report Number(s):
- CONF-950402--
- Country of Publication:
- United States
- Language:
- English
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