Molecular Insights into Crimean-Congo Hemorrhagic Fever Virus

Zivcec, Marko; Scholte, Florine; Spiropoulou, Christina; Spengler, Jessica; Bergeron, Éric

doi:10.3390/v8040106

Title: Molecular Insights into Crimean-Congo Hemorrhagic Fever Virus

Journal Article · Thu Apr 21 00:00:00 EDT 2016 · Viruses

DOI:https://doi.org/10.3390/v8040106· OSTI ID:1258588

Zivcec, Marko ^[1]; Scholte, Florine ^[1]; Spiropoulou, Christina ^[1]; Spengler, Jessica ^[1]; Bergeron, Éric ^[1]

Centers for Disease Control and Prevention, Atlanta, GA (United States). Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology

Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne pathogen that causes high morbidity and mortality. Efficacy of vaccines and antivirals to treat human CCHFV infections remains limited and controversial. Research into pathology and underlying molecular mechanisms of CCHFV and other nairoviruses is limited. Significant progress has been made in our understanding of CCHFV replication and pathogenesis in the past decade. Here we review the most recent molecular advances in CCHFV-related research, and provide perspectives on future research.

View Accepted Manuscript (DOE)

Cite

Export

Save

Research Organization:: Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN (United States); Centers for Disease Control and Prevention, Atlanta, GA (United States). Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology

Sponsoring Organization:: USDOE; Centers for Disease Control and Prevention

OSTI ID:: 1258588

Journal Information:: Viruses, Vol. 8, Issue 4; ISSN 1999-4915

Publisher:: MDPICopyright Statement

Country of Publication:: United States

Language:: English

Citation Metrics:

Cited by: 67 works

Citation information provided by
Web of Science

References (122)

A Novel Vaccine against Crimean-Congo Haemorrhagic Fever Protects 100% of Animals against Lethal Challenge in a Mouse Model Buttigieg, Karen R.; Dowall, Stuart D.; Findlay-Wilson, Stephen PLoS ONE, Vol. 9, Issue 3 https://doi.org/10.1371/journal.pone.0091516	journal	March 2014
Crimean-Congo hemorrhagic fever virus nucleoprotein reveals endonuclease activity in bunyaviruses Guo, Y.; Wang, W.; Ji, W. Proceedings of the National Academy of Sciences, Vol. 109, Issue 13 https://doi.org/10.1073/pnas.1200808109	journal	March 2012
Virus Detection and Monitoring of Viral Load in Crimean-Congo Hemorrhagic Fever Virus Patients Wölfel, Roman; Paweska, Janusz T.; Petersen, Nadine Emerging Infectious Diseases, Vol. 13, Issue 7 https://doi.org/10.3201/eid1307.070068	journal	July 2007
Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains Akutsu, M.; Ye, Y.; Virdee, S. Proceedings of the National Academy of Sciences, Vol. 108, Issue 6 https://doi.org/10.1073/pnas.1015287108	journal	January 2011
A Crimean-Congo hemorrhagic fever (CCHF) viral vaccine expressing nucleoprotein is immunogenic but fails to confer protection against lethal disease Dowall, Sd; Buttigieg, Kr; Findlay-Wilson, Sjd Human Vaccines & Immunotherapeutics, Vol. 12, Issue 2 https://doi.org/10.1080/21645515.2015.1078045	journal	August 2015
The effectiveness of routine laboratory findings in determining disease severity in patients with Crimean-Congo hemorrhagic fever: Severity prediction criteria Yilmaz, Gurdal; Koksal, Iftihar; Topbas, Murat Journal of Clinical Virology, Vol. 47, Issue 4 https://doi.org/10.1016/j.jcv.2010.01.010	journal	April 2010
Morphology and morphogenesis of Crimean Hemorrhagic Fever Virus Korolev, M. B.; Donets, M. A.; Rubin, S. G. Archives of Virology, Vol. 50, Issue 1-2 https://doi.org/10.1007/BF01318011	journal	March 1976
Healthy individuals’ immune response to the Bulgarian Crimean-Congo hemorrhagic fever virus vaccine Mousavi-Jazi, Mehrdad; Karlberg, Helen; Papa, Anna Vaccine, Vol. 30, Issue 44 https://doi.org/10.1016/j.vaccine.2012.08.003	journal	September 2012
Evaluation of Antiviral Efficacy of Ribavirin, Arbidol, and T-705 (Favipiravir) in a Mouse Model for Crimean-Congo Hemorrhagic Fever Oestereich, Lisa; Rieger, Toni; Neumann, Melanie PLoS Neglected Tropical Diseases, Vol. 8, Issue 5 https://doi.org/10.1371/journal.pntd.0002804	journal	May 2014
Interferon and cytokine responses to Crimean Congo hemorrhagic fever virus; an emerging and neglected viral zonoosis Weber, Friedemann; Mirazimi, Ali Cytokine & Growth Factor Reviews, Vol. 19, Issue 5-6 https://doi.org/10.1016/j.cytogfr.2008.11.001	journal	October 2008
Genomic analysis of rice stripe virus Zhejiang isolate shows the presence of an OTU-like domain in the RNA1 protein and a novel sequence motif conserved within the intergenic regions of ambisense segments of tenuiviruses Zhang, H. -M.; Yang, J.; Sun, H. -R. Archives of Virology, Vol. 152, Issue 10 https://doi.org/10.1007/s00705-007-1013-2	journal	June 2007
The N-Terminal Domain of the Arenavirus L Protein Is an RNA Endonuclease Essential in mRNA Transcription Morin, Benjamin; Coutard, Bruno; Lelke, Michaela PLoS Pathogens, Vol. 6, Issue 9 https://doi.org/10.1371/journal.ppat.1001038	journal	September 2010
Immunization of Knock-Out α/β Interferon Receptor Mice against High Lethal Dose of Crimean-Congo Hemorrhagic Fever Virus with a Cell Culture Based Vaccine Canakoglu, Nurettin; Berber, Engin; Tonbak, Sukru PLOS Neglected Tropical Diseases, Vol. 9, Issue 3 https://doi.org/10.1371/journal.pntd.0003579	journal	March 2015
Viral Load as a Predictor of Outcome in Crimean-Congo Hemorrhagic Fever Cevik, M. A.; Erbay, A.; Bodur, H. Clinical Infectious Diseases, Vol. 45, Issue 7 https://doi.org/10.1086/521244	journal	October 2007
Nucleolin and the Packaging Signal, ψ, Promote the Budding of Human Immunodeficiency Virus Type-1 (HIV-1) Ueno, Tomonori; Tokunaga, Kenzo; Sawa, Hirofumi Microbiology and Immunology, Vol. 48, Issue 2 https://doi.org/10.1111/j.1348-0421.2004.tb03496.x	journal	February 2004
RIG-I Mediates an Antiviral Response to Crimean-Congo Hemorrhagic Fever Virus Spengler, Jessica R.; Patel, Jenish R.; Chakrabarti, Ayan K. Journal of Virology, Vol. 89, Issue 20 https://doi.org/10.1128/JVI.01643-15	journal	July 2015
Ovarian Tumor Domain-Containing Viral Proteases Evade Ubiquitin- and ISG15-Dependent Innate Immune Responses Frias-Staheli, Natalia; Giannakopoulos, Nadia V.; Kikkert, Marjolein Cell Host & Microbe, Vol. 2, Issue 6 https://doi.org/10.1016/j.chom.2007.09.014	journal	December 2007
PLP2, a potent deubiquitinase from murine hepatitis virus, strongly inhibits cellular type I interferon production Zheng, Dahai; Chen, Gang; Guo, Beichu Cell Research, Vol. 18, Issue 11 https://doi.org/10.1038/cr.2008.294	journal	October 2008
Crimean-Congo Hemorrhagic Fever Virus Entry into Host Cells Occurs through the Multivesicular Body and Requires ESCRT Regulators Shtanko, Olena; Nikitina, Raisa A.; Altuntas, Cengiz Z. PLoS Pathogens, Vol. 10, Issue 9 https://doi.org/10.1371/journal.ppat.1004390	journal	September 2014
ATP-Dependent Effector-like Functions of RIG-I-like Receptors Yao, Hui; Dittmann, Meike; Peisley, Alys Molecular Cell, Vol. 58, Issue 3 https://doi.org/10.1016/j.molcel.2015.03.014	journal	May 2015
RNA helicase retinoic acid-inducible gene I as a sensor of Hantaan virus replication Lee, M. -H.; Lalwani, P.; Raftery, M. J. Journal of General Virology, Vol. 92, Issue 9 https://doi.org/10.1099/vir.0.032367-0	journal	June 2011
Structural basis for encapsidation of genomic RNA by La Crosse Orthobunyavirus nucleoprotein Reguera, J.; Malet, H.; Weber, F. Proceedings of the National Academy of Sciences, Vol. 110, Issue 18 https://doi.org/10.1073/pnas.1302298110	journal	April 2013
Ribavirin for Crimean-Congo hemorrhagic fever: systematic review and meta-analysis Soares-Weiser, Karla; Thomas, Sherine; G., Gail Thomson BMC Infectious Diseases, Vol. 10, Issue 1 https://doi.org/10.1186/1471-2334-10-207	journal	July 2010
Evaluation of Serum Levels of Interleukin (IL)–6, IL‐10, and Tumor Necrosis Factor–α in Patients with Crimean‐Congo Hemorrhagic Fever Ergonul, Onder; Tuncbilek, Semra; Baykam, Nurcan The Journal of Infectious Diseases, Vol. 193, Issue 7 https://doi.org/10.1086/500836	journal	April 2006
Identification of a putative Crimean-Congo hemorrhagic fever virus entry factor Xiao, Xiaodong; Feng, Yang; Zhu, Zhongyu Biochemical and Biophysical Research Communications, Vol. 411, Issue 2 https://doi.org/10.1016/j.bbrc.2011.06.109	journal	July 2011
Crimean Congo hemorrhagic fever virus infects human monocyte-derived dendritic cells Connolly-Andersen, Anne-Marie; Douagi, Iyadh; Kraus, Annette A. Virology, Vol. 390, Issue 2 https://doi.org/10.1016/j.virol.2009.06.010	journal	August 2009
Cap binding and immune evasion revealed by Lassa nucleoprotein structure Qi, Xiaoxuan; Lan, Shuiyun; Wang, Wenjian Nature, Vol. 468, Issue 7325 https://doi.org/10.1038/nature09605	journal	November 2010
Coagulopathy parameters in patients with Crimean-Congo hemorrhagic fever and its relation with mortality Onguru, P.; Dagdas, S.; Bodur, H. Journal of Clinical Laboratory Analysis, Vol. 24, Issue 3 https://doi.org/10.1002/jcla.20383	journal	January 2010
Bunyaviridae RNA Polymerases (L-Protein) Have an N-Terminal, Influenza-Like Endonuclease Domain, Essential for Viral Cap-Dependent Transcription Reguera, Juan; Weber, Friedemann; Cusack, Stephen PLoS Pathogens, Vol. 6, Issue 9 https://doi.org/10.1371/journal.ppat.1001101	journal	September 2010
Structure of the Rift Valley fever virus nucleocapsid protein reveals another architecture for RNA encapsidation Raymond, D. D.; Piper, M. E.; Gerrard, S. R. Proceedings of the National Academy of Sciences, Vol. 107, Issue 26 https://doi.org/10.1073/pnas.1001760107	journal	June 2010
Crystal structure of the Lassa virus nucleoprotein-RNA complex reveals a gating mechanism for RNA binding Hastie, K. M.; Liu, T.; Li, S. Proceedings of the National Academy of Sciences, Vol. 108, Issue 48 https://doi.org/10.1073/pnas.1108515108	journal	November 2011
Differential activation profiles of Crimean-Congo hemorrhagic fever virus- and Dugbe virus-infected antigen-presenting cells Peyrefitte, C. N.; Perret, M.; Garcia, S. Journal of General Virology, Vol. 91, Issue 1 https://doi.org/10.1099/vir.0.015701-0	journal	October 2009
Identification of nucleolin as a cellular receptor for human respiratory syncytial virus Tayyari, Farnoosh; Marchant, David; Moraes, Theo J. Nature Medicine, Vol. 17, Issue 9 https://doi.org/10.1038/nm.2444	journal	August 2011
Role of actin filaments in targeting of Crimean Congo hemorrhagic fever virus nucleocapsid protein to perinuclear regions of mammalian cells: Crimean-Congo Hemorrhagic Fever Virus NP Andersson, Ida; Simon, Melinda; Lundkvist, Åke Journal of Medical Virology, Vol. 72, Issue 1 https://doi.org/10.1002/jmv.10560	journal	November 2003
Clinical and laboratory features of Crimean-Congo hemorrhagic fever: predictors of fatality Çevik, Mustafa A.; Erbay, Ayse; Bodur, Hürrem International Journal of Infectious Diseases, Vol. 12, Issue 4 https://doi.org/10.1016/j.ijid.2007.09.010	journal	July 2008
Mapping of the interaction domains of the Crimean-Congo hemorrhagic fever virus nucleocapsid protein Macleod, J. M. L.; Marmor, H.; Garcia-Sastre, A. Journal of General Virology, Vol. 96, Issue Pt_3 https://doi.org/10.1099/vir.0.071332-0	journal	November 2014
Arterivirus and Nairovirus Ovarian Tumor Domain-Containing Deubiquitinases Target Activated RIG-I To Control Innate Immune Signaling van Kasteren, P. B.; Beugeling, C.; Ninaber, D. K. Journal of Virology, Vol. 86, Issue 2 https://doi.org/10.1128/JVI.06277-11	journal	November 2011
Review Article 1: The Epidemiology of Tick-Borne Crimean-Congo Hemorrhagic Fever in Asia, Europe, and Africa23 Hoogstraal, Harry Journal of Medical Entomology, Vol. 15, Issue 4 https://doi.org/10.1093/jmedent/15.4.307	journal	May 1979
DUBA: A Deubiquitinase That Regulates Type I Interferon Production Kayagaki, N.; Phung, Q.; Chan, S. Science, Vol. 318, Issue 5856 https://doi.org/10.1126/science.1145918	journal	December 2007
The efficacy of ribavirin in the treatment of Crimean-Congo hemorrhagic fever in Eastern Black Sea region in Turkey Koksal, Iftihar; Yilmaz, Gurdal; Aksoy, Firdevs Journal of Clinical Virology, Vol. 47, Issue 1 https://doi.org/10.1016/j.jcv.2009.11.007	journal	January 2010
TRIM26 Negatively Regulates Interferon-β Production and Antiviral Response through Polyubiquitination and Degradation of Nuclear IRF3 Wang, Peng; Zhao, Wei; Zhao, Kai PLOS Pathogens, Vol. 11, Issue 3 https://doi.org/10.1371/journal.ppat.1004726	journal	March 2015
Structural basis for the removal of ubiquitin and interferon-stimulated gene 15 by a viral ovarian tumor domain-containing protease James, T. W.; Frias-Staheli, N.; Bacik, J. -P. Proceedings of the National Academy of Sciences, Vol. 108, Issue 6 https://doi.org/10.1073/pnas.1013388108	journal	January 2011
Crimean–Congo hemorrhagic fever Whitehouse, C. Antiviral Research, Vol. 64, Issue 3 https://doi.org/10.1016/S0166-3542(04)00163-9	journal	December 2004
Viral Load and Crimean-Congo Hemorrhagic Fever Papa, Anna; Drosten, Christian; Bino, Silvia Emerging Infectious Diseases, Vol. 13, Issue 5 https://doi.org/10.3201/eid1305.061588	journal	May 2007
Production of CCHF virus-like particle by a baculovirus-insect cell expression system Zhou, Zhao-rui; Wang, Man-li; Deng, Fei Virologica Sinica, Vol. 26, Issue 5 https://doi.org/10.1007/s12250-011-3209-6	journal	October 2011
Re-Evaluation of 400 Crimean-Congo Hemorrhagic Fever Cases in an Endemic Area: Is Ribavirin Treatment Suitable? Duygu, Fazilet; Kaya, Turan; Baysan, Pinar Vector-Borne and Zoonotic Diseases, Vol. 12, Issue 9 https://doi.org/10.1089/vbz.2011.0694	journal	September 2012
Structural insights into RNA encapsidation and helical assembly of the Toscana virus nucleoprotein Olal, Daniel; Dick, Alexej; Woods, Virgil L. Nucleic Acids Research, Vol. 42, Issue 9 https://doi.org/10.1093/nar/gku229	journal	March 2014
Complementarity, sequence and structural elements within the 3' and 5' non-coding regions of the Bunyamwera orthobunyavirus S segment determine promoter strength Kohl, A. Journal of General Virology, Vol. 85, Issue 11 https://doi.org/10.1099/vir.0.80407-0	journal	November 2004
Crimean-Congo haemorrhagic fever replication interplays with regulation mechanisms of apoptosis Karlberg, H.; Tan, Y. -J.; Mirazimi, A. Journal of General Virology, Vol. 96, Issue Pt_3 https://doi.org/10.1099/jgv.0.000011	journal	December 2014
Serial expression of the truncated fragments of the nucleocapsid protein of CCHFV and identification of the epitope region Wei, Peng-fei; Luo, Yan-jun; Li, Tian-xian Virologica Sinica, Vol. 25, Issue 1 https://doi.org/10.1007/s12250-010-3067-7	journal	February 2010
Recovery of Recombinant Crimean Congo Hemorrhagic Fever Virus Reveals a Function for Non-structural Glycoproteins Cleavage by Furin Bergeron, Éric; Zivcec, Marko; Chakrabarti, Ayan K. PLOS Pathogens, Vol. 11, Issue 5 https://doi.org/10.1371/journal.ppat.1004879	journal	May 2015
Crimean–Congo hemorrhagic fever virus genome L RNA segment and encoded protein Honig, Jessica E.; Osborne, Jane C.; Nichol, Stuart T. Virology, Vol. 321, Issue 1 https://doi.org/10.1016/j.virol.2003.09.042	journal	March 2004
Identification of a Novel C-Terminal Cleavage of Crimean-Congo Hemorrhagic Fever Virus PreGN That Leads to Generation of an NSM Protein Altamura, L. A.; Bertolotti-Ciarlet, A.; Teigler, J. Journal of Virology, Vol. 81, Issue 12 https://doi.org/10.1128/JVI.02730-06	journal	April 2007
Sequence determination of the Crimean–Congo hemorrhagic fever virus L segment Kinsella, Erin; Martin, Sandra G.; Grolla, Allen Virology, Vol. 321, Issue 1 https://doi.org/10.1016/j.virol.2003.09.046	journal	March 2004
Crimean-Congo hemorrhagic fever virus entry and replication is clathrin-, pH- and cholesterol-dependent Simon, M.; Johansson, C.; Mirazimi, A. Journal of General Virology, Vol. 90, Issue 1 https://doi.org/10.1099/vir.0.006387-0	journal	January 2009
Inhibition of Interferon Induction and Action by the Nairovirus Nairobi Sheep Disease Virus/Ganjam Virus Holzer, Barbara; Bakshi, Siddharth; Bridgen, Anne PLoS ONE, Vol. 6, Issue 12 https://doi.org/10.1371/journal.pone.0028594	journal	December 2011
Cytokine levels in Crimean-Congo hemorrhagic fever Papa, Anna; Bino, Silva; Velo, Enkelejda Journal of Clinical Virology, Vol. 36, Issue 4 https://doi.org/10.1016/j.jcv.2006.04.007	journal	August 2006
Proteolytic Processing of Marburg Virus Glycoprotein Volchkov, Viktor E.; Volchkova, Valentina A.; Ströher, Ute Virology, Vol. 268, Issue 1 https://doi.org/10.1006/viro.1999.0110	journal	March 2000
Physicochemical Characteristics, Morphology and Morphogenesis of Virions of the Causative Agent of Crimean Hemorrhagic Fever Donets, Mikhail A.; Chumakov, Mikhail P.; Korolev, Mikhail B. Intervirology, Vol. 8, Issue 5 https://doi.org/10.1159/000148904	journal	January 1977
Crimean-Congo hemorrhagic fever: History, epidemiology, pathogenesis, clinical syndrome and genetic diversity Bente, Dennis A.; Forrester, Naomi L.; Watts, Douglas M. Antiviral Research, Vol. 100, Issue 1 https://doi.org/10.1016/j.antiviral.2013.07.006	journal	October 2013
Crimean-Congo Hemorrhagic Fever Virus Subunit Vaccines Induce High Levels of Neutralizing Antibodies But No Protection in STAT1 Knockout Mice Kortekaas, Jeroen; Vloet, Rianka P. M.; McAuley, Alexander J. Vector-Borne and Zoonotic Diseases, Vol. 15, Issue 12 https://doi.org/10.1089/vbz.2015.1855	journal	December 2015
Site 1 Protease Is Required for Proteolytic Processing of the Glycoproteins of the South American Hemorrhagic Fever Viruses Junin, Machupo, and Guanarito Rojek, J. M.; Lee, A. M.; Nguyen, N. Journal of Virology, Vol. 82, Issue 12 https://doi.org/10.1128/JVI.02392-07	journal	April 2008
Influence of laboratory animal hosts on the life cycle of Hyalomma marginatum and implications for an in vivo transmission model for Crimean-Congo hemorrhagic fever virus Gargili, Aysen; Thangamani, Saravanan; Bente, Dennis Frontiers in Cellular and Infection Microbiology, Vol. 3 https://doi.org/10.3389/fcimb.2013.00039	journal	January 2013
Human defined antigenic region on the nucleoprotein of Crimean-Congo hemorrhagic fever virus identified using truncated proteins and a bioinformatics approach Burt, F. J.; Samudzi, R. R.; Randall, C. Journal of Virological Methods, Vol. 193, Issue 2 https://doi.org/10.1016/j.jviromet.2013.07.055	journal	November 2013
MERS-CoV papain-like protease has deISGylating and deubiquitinating activities Mielech, Anna M.; Kilianski, Andy; Baez-Santos, Yahira M. Virology, Vol. 450-451 https://doi.org/10.1016/j.virol.2013.11.040	journal	February 2014
Type I interferon inhibits Crimean-Congo hemorrhagic fever virus in human target cells Andersson, Ida; Lundkvist, Åke; Haller, Otto Journal of Medical Virology, Vol. 78, Issue 2 https://doi.org/10.1002/jmv.20530	journal	January 2005
Characterization of putative Japanese encephalitis virus receptor molecules on microglial cells Thongtan, Thananya; Wikan, Nitwara; Wintachai, Phitchayapak Journal of Medical Virology, Vol. 84, Issue 4 https://doi.org/10.1002/jmv.23248	journal	February 2012
The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit Dias, Alexandre; Bouvier, Denis; Crépin, Thibaut Nature, Vol. 458, Issue 7240 https://doi.org/10.1038/nature07745	journal	February 2009
Ubiquitin-Induced Oligomerization of the RNA Sensors RIG-I and MDA5 Activates Antiviral Innate Immune Response Jiang, Xiaomo; Kinch, Lisa N.; Brautigam, Chad A. Immunity, Vol. 36, Issue 6 https://doi.org/10.1016/j.immuni.2012.03.022	journal	June 2012
Assessment of Inhibitors of Pathogenic Crimean-Congo Hemorrhagic Fever Virus Strains Using Virus-Like Particles Zivcec, Marko; Metcalfe, Maureen G.; Albariño, César G. PLOS Neglected Tropical Diseases, Vol. 9, Issue 12 https://doi.org/10.1371/journal.pntd.0004259	journal	December 2015
Crimean-Congo Hemorrhagic Fever Virus Glycoprotein Proteolytic Processing by Subtilase SKI-1 Vincent, M. J.; Sanchez, A. J.; Erickson, B. R. Journal of Virology, Vol. 77, Issue 16 https://doi.org/10.1128/JVI.77.16.8640-8649.2003	journal	July 2003
Structural Characterization of the Crimean-Congo Hemorrhagic Fever Virus Gn Tail Provides Insight into Virus Assembly Estrada, D. Fernando; De Guzman, Roberto N. Journal of Biological Chemistry, Vol. 286, Issue 24 https://doi.org/10.1074/jbc.M110.216515	journal	April 2011
A Compact Viral Processing Proteinase/Ubiquitin Hydrolase from the OTU Family Lombardi, Charlotte; Ayach, Maya; Beaurepaire, Lionel PLoS Pathogens, Vol. 9, Issue 8 https://doi.org/10.1371/journal.ppat.1003560	journal	August 2013
Viral Load as Predictor of Crimean-Congo Hemorrhagic Fever Outcome Duh, Darja; Saksida, Ana; Petrovec, Miroslav Emerging Infectious Diseases, Vol. 13, Issue 11 https://doi.org/10.3201/eid1311.070222	journal	November 2007
Crystal structure of glycoprotein C from Rift Valley fever virus Dessau, M.; Modis, Y. Proceedings of the National Academy of Sciences, Vol. 110, Issue 5 https://doi.org/10.1073/pnas.1217780110	journal	January 2013
Viral envelope glycoprotein processing by proprotein convertases Pasquato, Antonella; Ramos da Palma, Joel; Galan, Clara Antiviral Research, Vol. 99, Issue 1 https://doi.org/10.1016/j.antiviral.2013.04.013	journal	July 2013
Processing of the Ebola virus glycoprotein by the proprotein convertase furin Volchkov, V. E.; Feldmann, H.; Volchkova, V. A. Proceedings of the National Academy of Sciences, Vol. 95, Issue 10 https://doi.org/10.1073/pnas.95.10.5762	journal	May 1998
Crimean-Congo Hemorrhagic Fever Virus-Encoded Ovarian Tumor Protease Activity Is Dispensable for Virus RNA Polymerase Function Bergeron, E.; Albarino, C. G.; Khristova, M. L. Journal of Virology, Vol. 84, Issue 1 https://doi.org/10.1128/JVI.01859-09	journal	October 2009
Tick Cell Lines for Study of Crimean-Congo Hemorrhagic Fever Virus and Other Arboviruses Bell-Sakyi, Lesley; Kohl, Alain; Bente, Dennis A. Vector-Borne and Zoonotic Diseases, Vol. 12, Issue 9 https://doi.org/10.1089/vbz.2011.0766	journal	September 2012
Structural and Functional Diversity of Nairovirus-Encoded Nucleoproteins Wang, Wenming; Liu, Xiang; Wang, Xu Journal of Virology, Vol. 89, Issue 23 https://doi.org/10.1128/JVI.01680-15	journal	August 2015
Analysis of risk-factors among patients with Crimean-Congo haemorrhagic fever virus infection: severity criteria revisited Ergonul, O.; Celikbas, A.; Baykam, N. Clinical Microbiology and Infection, Vol. 12, Issue 6 https://doi.org/10.1111/j.1469-0691.2006.01445.x	journal	June 2006
Proteomic identification of proteins conjugated to ISG15 in mouse and human cells Giannakopoulos, Nadia V.; Luo, Jiann-Kae; Papov, Vladimir Biochemical and Biophysical Research Communications, Vol. 336, Issue 2 https://doi.org/10.1016/j.bbrc.2005.08.132	journal	October 2005
Crimean–Congo hemorrhagic fever virus utilizes a clathrin- and early endosome-dependent entry pathway Garrison, Aura R.; Radoshitzky, Sheli R.; Kota, Krishna P. Virology, Vol. 444, Issue 1-2 https://doi.org/10.1016/j.virol.2013.05.030	journal	September 2013
Nucleolin: The most abundant multifunctional phosphoprotein of nucleolus Tajrishi, Marjan M.; Tuteja, Renu; Tuteja, Narendra Communicative & Integrative Biology, Vol. 4, Issue 3 https://doi.org/10.4161/cib.4.3.14884	journal	May 2011
N-linked glycosylation of Gn (but not Gc) is important for Crimean Congo hemorrhagic fever virus glycoprotein localization and transport Erickson, Bobbie R.; Deyde, Varough; Sanchez, Angela J. Virology, Vol. 361, Issue 2 https://doi.org/10.1016/j.virol.2006.11.023	journal	May 2007
Processing of Genome 5′ Termini as a Strategy of Negative-Strand RNA Viruses to Avoid RIG-I-Dependent Interferon Induction Habjan, Matthias; Andersson, Ida; Klingström, Jonas PLoS ONE, Vol. 3, Issue 4 https://doi.org/10.1371/journal.pone.0002032	journal	April 2008
Pathogenesis and Immune Response of Crimean-Congo Hemorrhagic Fever Virus in a STAT-1 Knockout Mouse Model Bente, D. A.; Alimonti, J. B.; Shieh, W. -J. Journal of Virology, Vol. 84, Issue 21 https://doi.org/10.1128/JVI.01383-10	journal	August 2010
Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways Zhao, C.; Denison, C.; Huibregtse, J. M. Proceedings of the National Academy of Sciences, Vol. 102, Issue 29 https://doi.org/10.1073/pnas.0504754102	journal	July 2005
Crimean-Congo Hemorrhagic Fever Shayan, Sara; Bokaean, Mohammad; Shahrivar, Mona Ranjvar Laboratory Medicine, Vol. 46, Issue 3 https://doi.org/10.1309/lmn1p2frz7bkzsco	journal	August 2015
Crimean?Congo hemorrhagic fever Whitehouse, C. Antiviral Research, Vol. 64, Issue 3 https://doi.org/10.1016/j.antiviral.2004.08.001	journal	December 2004
A novel superfamily of predicted cysteine proteases from eukaryotes, viruses and Chlamydia pneumoniae Makarova, Kira S.; Aravind, L.; Koonin, Eugene V. Trends in Biochemical Sciences, Vol. 25, Issue 2 https://doi.org/10.1016/s0968-0004(99)01530-3	journal	February 2000
Crimean-Congo haemorrhagic fever Ergönül, Önder The Lancet Infectious Diseases, Vol. 6, Issue 4 https://doi.org/10.1016/s1473-3099(06)70435-2	journal	April 2006
Enzyme-linked immunosorbent assays for the detection of antibody to Crimean-Congo haemorrhagic fever virus in the sera of livestock and wild vertebrates Burt, F. J.; Swanepoel, R.; Braack, L. E. O. Epidemiology and Infection, Vol. 111, Issue 3 https://doi.org/10.1017/s0950268800057277	journal	December 1993
Induction of Caspase Activation and Cleavage of the Viral Nucleocapsid Protein in Different Cell Types during Crimean-Congo Hemorrhagic Fever Virus Infection Karlberg, Helen; Tan, Yee-Joo; Mirazimi, Ali Journal of Biological Chemistry, Vol. 286, Issue 5 https://doi.org/10.1074/jbc.m110.149369	journal	December 2010
Activation of Double-stranded RNA-activated Protein Kinase (PKR) by Interferon-stimulated Gene 15 (ISG15) Modification Down-regulates Protein Translation Okumura, Fumihiko; Okumura, Akiko J.; Uematsu, Keiji Journal of Biological Chemistry, Vol. 288, Issue 4 https://doi.org/10.1074/jbc.m112.401851	journal	December 2012
The Non-structural Protein of Crimean-Congo Hemorrhagic Fever Virus Disrupts the Mitochondrial Membrane Potential and Induces Apoptosis Barnwal, Bhaskar; Karlberg, Helen; Mirazimi, Ali Journal of Biological Chemistry, Vol. 291, Issue 2 https://doi.org/10.1074/jbc.m115.667436	journal	November 2015
Crimean-Congo hemorrhagic fever Vorou, Regina; Pierroutsakos, Ioannis N.; Maltezou, Helen C. Current Opinion in Infectious Diseases, Vol. 20, Issue 5 https://doi.org/10.1097/qco.0b013e3282a56a0a	journal	January 2007
Ex Vivo Stability of the Rodent-Borne Hantaan Virus in Comparison to That of Arthropod-Borne Members of the Bunyaviridae Family Hardestam, J.; Simon, M.; Hedlund, K. O. Applied and Environmental Microbiology, Vol. 73, Issue 8 https://doi.org/10.1128/aem.02869-06	journal	March 2007
Interacting Roles of Immune Mechanisms and Viral Load in the Pathogenesis of Crimean-Congo Hemorrhagic Fever Saksida, A.; Duh, D.; Wraber, B. Clinical and Vaccine Immunology, Vol. 17, Issue 7 https://doi.org/10.1128/cvi.00530-09	journal	May 2010
Antagonism of Type I Interferon Responses by New World Hantaviruses Levine, J. R.; Prescott, J.; Brown, K. S. Journal of Virology, Vol. 84, Issue 22 https://doi.org/10.1128/jvi.00916-10	journal	September 2010
Structure, Function, and Evolution of the Crimean-Congo Hemorrhagic Fever Virus Nucleocapsid Protein Carter, S. D.; Surtees, R.; Walter, C. T. Journal of Virology, Vol. 86, Issue 20 https://doi.org/10.1128/jvi.01555-12	journal	August 2012
Structure of Crimean-Congo Hemorrhagic Fever Virus Nucleoprotein: Superhelical Homo-Oligomers and the Role of Caspase-3 Cleavage Wang, Y.; Dutta, S.; Karlberg, H. Journal of Virology, Vol. 86, Issue 22 https://doi.org/10.1128/jvi.01627-12	journal	September 2012
Crimean-Congo Hemorrhagic Fever Virus Glycoprotein Processing by the Endoprotease SKI-1/S1P Is Critical for Virus Infectivity Bergeron, E.; Vincent, M. J.; Nichol, S. T. Journal of Virology, Vol. 81, Issue 23 https://doi.org/10.1128/jvi.01647-07	journal	September 2007
Negative Feedback Regulation of RIG-I-Mediated Antiviral Signaling by Interferon-Induced ISG15 Conjugation Kim, M. -J.; Hwang, S. -Y.; Imaizumi, T. Journal of Virology, Vol. 82, Issue 3 https://doi.org/10.1128/jvi.01650-07	journal	December 2007
Cleavage of the Junin Virus Nucleoprotein Serves a Decoy Function To Inhibit the Induction of Apoptosis during Infection Wolff, S.; Becker, S.; Groseth, A. Journal of Virology, Vol. 87, Issue 1 https://doi.org/10.1128/jvi.01929-12	journal	October 2012
Basolateral Entry and Release of Crimean-Congo Hemorrhagic Fever Virus in Polarized MDCK-1 Cells Connolly-Andersen, A. -M.; Magnusson, K. -E.; Mirazimi, A. Journal of Virology, Vol. 81, Issue 5 https://doi.org/10.1128/jvi.02070-06	journal	December 2006
Deubiquitinating and Interferon Antagonism Activities of Coronavirus Papain-Like Proteases Clementz, M. A.; Chen, Z.; Banach, B. S. Journal of Virology, Vol. 84, Issue 9 https://doi.org/10.1128/jvi.02406-09	journal	February 2010
Crimean-Congo Hemorrhagic Fever Virus Activates Endothelial Cells Connolly-Andersen, A. -M.; Moll, G.; Andersson, C. Journal of Virology, Vol. 85, Issue 15 https://doi.org/10.1128/jvi.02469-10	journal	June 2011
Structural Analysis of a Viral Ovarian Tumor Domain Protease from the Crimean-Congo Hemorrhagic Fever Virus in Complex with Covalently Bonded Ubiquitin Capodagli, G. C.; McKercher, M. A.; Baker, E. A. Journal of Virology, Vol. 85, Issue 7 https://doi.org/10.1128/jvi.02496-10	journal	January 2011
A Shared Transcription Termination Signal on Negative and Ambisense RNA Genome Segments of Rift Valley Fever, Sandfly Fever Sicilian, and Toscana Viruses Albarino, C. G.; Bird, B. H.; Nichol, S. T. Journal of Virology, Vol. 81, Issue 10 https://doi.org/10.1128/jvi.02778-06	journal	February 2007
A Virus-Like Particle System Identifies the Endonuclease Domain of Crimean-Congo Hemorrhagic Fever Virus Devignot, Stephanie; Bergeron, Eric; Nichol, Stuart Journal of Virology, Vol. 89, Issue 11 https://doi.org/10.1128/jvi.03691-14	journal	March 2015
Circular forms of Uukuniemi virion RNA: an electron microscopic study. Hewlett, M. J.; Pettersson, R. F.; Baltimore, D. Journal of Virology, Vol. 21, Issue 3 https://doi.org/10.1128/jvi.21.3.1085-1093.1977	journal	January 1977
The 5' ends of Hantaan virus (Bunyaviridae) RNAs suggest a prime-and-realign mechanism for the initiation of RNA synthesis. Garcin, D.; Lezzi, M.; Dobbs, M. Journal of virology, Vol. 69, Issue 9 https://doi.org/10.1128/jvi.69.9.5754-5762.1995	journal	January 1995
Characterization of the Glycoproteins of Crimean-Congo Hemorrhagic Fever Virus Sanchez, A. J.; Vincent, M. J.; Nichol, S. T. Journal of Virology, Vol. 76, Issue 14 https://doi.org/10.1128/jvi.76.14.7263-7275.2002	journal	July 2002
Human MxA Protein Inhibits the Replication of Crimean-Congo Hemorrhagic Fever Virus Andersson, I.; Bladh, L.; Mousavi-Jazi, M. Journal of Virology, Vol. 78, Issue 8 https://doi.org/10.1128/jvi.78.8.4323-4329.2004	journal	March 2004
Cellular Localization and Antigenic Characterization of Crimean-Congo Hemorrhagic Fever Virus Glycoproteins Bertolotti-Ciarlet, A.; Smith, J.; Strecker, K. Journal of Virology, Vol. 79, Issue 10 https://doi.org/10.1128/jvi.79.10.6152-6161.2005	journal	April 2005
Role of the Conserved Nucleotide Mismatch within 3'- and 5'-Terminal Regions of Bunyamwera Virus in Signaling Transcription Barr, J. N.; Wertz, G. W. Journal of Virology, Vol. 79, Issue 6 https://doi.org/10.1128/jvi.79.6.3586-3594.2005	journal	February 2005
Dual Role of the Lymphocytic Choriomeningitis Virus Intergenic Region in Transcription Termination and Virus Propagation Pinschewer, D. D.; Perez, M.; de la Torre, J. C. Journal of Virology, Vol. 79, Issue 7 https://doi.org/10.1128/jvi.79.7.4519-4526.2005	journal	March 2005
Crimean-Congo Hemorrhagic Fever Virus Glycoprotein Precursor Is Cleaved by Furin-Like and SKI-1 Proteases To Generate a Novel 38-Kilodalton Glycoprotein Sanchez, A. J.; Vincent, M. J.; Erickson, B. R. Journal of Virology, Vol. 80, Issue 1 https://doi.org/10.1128/jvi.80.1.514-525.2006	journal	December 2005
Positive Regulation of Interferon Regulatory Factor 3 Activation by Herc5 via ISG15 Modification Shi, H. X.; Yang, K.; Liu, X. Molecular and Cellular Biology, Vol. 30, Issue 10 https://doi.org/10.1128/mcb.01466-09	journal	March 2010
Protective mAbs and Cross-Reactive mAbs Raised by Immunization with Engineered Marburg Virus GPs Fusco, Marnie L.; Hashiguchi, Takao; Cassan, Robyn PLOS Pathogens, Vol. 11, Issue 6 https://doi.org/10.1371/journal.ppat.1005016	journal	June 2015
Correction: Protective mAbs and Cross-Reactive mAbs Raised by Immunization with Engineered Marburg Virus GPs Fusco, Marnie L.; Hashiguchi, Takao; Cassan, Robyn PLOS Pathogens, Vol. 11, Issue 10 https://doi.org/10.1371/journal.ppat.1005212	journal	October 2015

Cited By (16)

Tick-Borne Viruses Shi, Junming; Hu, Zhihong; Deng, Fei Virologica Sinica, Vol. 33, Issue 1 https://doi.org/10.1007/s12250-018-0019-0	journal	February 2018
Exploring Crimean-Congo Hemorrhagic Fever Virus-Induced Hepatic Injury Using Antibody-Mediated Type I Interferon Blockade in Mice Lindquist, Michael E.; Zeng, Xiankun; Altamura, Louis A. Journal of Virology, Vol. 92, Issue 21 https://doi.org/10.1128/jvi.01083-18	journal	August 2018
Global research trends of World Health Organization’s top eight emerging pathogens Sweileh, Waleed M. Globalization and Health, Vol. 13, Issue 1 https://doi.org/10.1186/s12992-017-0233-9	journal	February 2017
Co-Delivery Effect of CD24 on the Immunogenicity and Lethal Challenge Protection of a DNA Vector Expressing Nucleocapsid Protein of Crimean Congo Hemorrhagic Fever Virus Aligholipour Farzani, Touraj; Hanifehnezhad, Alireza; Földes, Katalin Viruses, Vol. 11, Issue 1 https://doi.org/10.3390/v11010075	journal	January 2019
The DEVD motif of Crimean-Congo hemorrhagic fever virus nucleoprotein is essential for viral replication in tick cells Salata, Cristiano; Monteil, Vanessa; Karlberg, Helen Taylor & Francis https://doi.org/10.6084/m9.figshare.7937024	text	January 2019
In silico structural elucidation of RNA-dependent RNA polymerase towards the identification of potential Crimean-Congo Hemorrhagic Fever Virus inhibitors Mirza, Muhammad Usman; Vanmeert, Michiel; Froeyen, Matheus Scientific Reports, Vol. 9, Issue 1 https://doi.org/10.1038/s41598-019-43129-2	journal	May 2019
Biochemical and structural studies reveal differences and commonalities among cap-snatching endonucleases from segmented negative-strand RNA viruses Holm, Tobias; Kopicki, Janine-Denise; Busch, Carola Journal of Biological Chemistry, Vol. 293, Issue 51 https://doi.org/10.1074/jbc.ra118.004373	journal	December 2018
GP38-targeting monoclonal antibodies protect adult mice against lethal Crimean-Congo hemorrhagic fever virus infection Golden, Joseph W.; Shoemaker, Charles J.; Lindquist, Michael E. Science Advances, Vol. 5, Issue 7 https://doi.org/10.1126/sciadv.aaw9535	journal	July 2019
Nucleocapsid protein-based vaccine provides protection in mice against lethal Crimean-Congo hemorrhagic fever virus challenge Zivcec, Marko; Safronetz, David; Scott, Dana P. PLOS Neglected Tropical Diseases, Vol. 12, Issue 7 https://doi.org/10.1371/journal.pntd.0006628	journal	July 2018
The DEVD motif of Crimean-Congo hemorrhagic fever virus nucleoprotein is essential for viral replication in tick cells Salata, Cristiano; Monteil, Vanessa; Karlberg, Helen Emerging Microbes & Infections, Vol. 7, Issue 1 https://doi.org/10.1038/s41426-018-0192-0	journal	December 2018
Tick-borne viruses BartÍKovÁ, P.; HolÍKovÁ, V.; KazimÍRovÁ, M. Acta virologica, Vol. 61, Issue 04 https://doi.org/10.4149/av_2017_403	journal	January 2017
Biochemical and structural studies reveal differences and commonalities among cap-snatching endonucleases from segmented negative-strand RNA viruses Holm, Tobias; Kopicki, Janine-Denise; Busch, Carola Deutsches Elektronen-Synchrotron, DESY, Hamburg https://doi.org/10.3204/pubdb-2018-04140	text	January 2018
Towards the first multi-epitope recombinant vaccine against Crimean-Congo hemorrhagic fever virus: A computer-aided vaccine design approach Nosrati, Mokhtar; Behbahani, Mandana; Mohabatkar, Hassan Journal of Biomedical Informatics, Vol. 93 https://doi.org/10.1016/j.jbi.2019.103160	journal	May 2019
Structure and Characterization of Crimean-Congo Hemorrhagic Fever Virus GP38 Mishra, Akaash K.; Moyer, Crystal L.; Abelson, Dafna M. Journal of Virology, Vol. 94, Issue 8 https://doi.org/10.1128/jvi.02005-19	journal	March 2020
Development of Multispecies Recombinant Nucleoprotein-Based Indirect ELISA for High-Throughput Screening of Crimean-Congo Hemorrhagic Fever Virus-Specific Antibodies Shrivastava, Neha; Shrivastava, Ambuj; Ninawe, Sandeep M. Frontiers in Microbiology, Vol. 10 https://doi.org/10.3389/fmicb.2019.01822	journal	August 2019
Animal Models for Crimean-Congo Hemorrhagic Fever Human Disease Viruses, Vol. 11, Issue 7 https://doi.org/10.3390/v11070590	journal	June 2019

Similar Records

Fluorescent Crimean-Congo hemorrhagic fever virus illuminates tissue tropism patterns and identifies early mononuclear phagocytic cell targets in Ifnar^-/- mice

Journal Article · Mon Dec 02 00:00:00 EST 2019 · PLoS Pathogens · OSTI ID:1258588

Welch, Stephen R.; Ritter, Jana M.; McElroy, Anita K.; +9 more

Structure and Characterization of Crimean-Congo Hemorrhagic Fever Virus GP38

Journal Article · Tue Mar 31 00:00:00 EDT 2020 · Journal of Virology · OSTI ID:1258588

Mishra, Akaash K.; Moyer, Crystal L.; Abelson, Dafna M.; +13 more

Seroepidemiological Studies of Crimean-Congo Hemorrhagic Fever Virus in Domestic and Wild Animals

Journal Article · Thu Jan 07 00:00:00 EST 2016 · PLoS Neglected Tropical Diseases (Online) · OSTI ID:1258588

Spengler, Jessica R.; Bergeron, Eric; Rollin, Pierre E.; +1 more

Related Subjects

60 APPLIED LIFE SCIENCES
Crimean-Congo hemorrhagic fever
viral hemorrhagic fever
reverse genetics
pathogenesis
tick-borne virus

Title: Molecular Insights into Crimean-Congo Hemorrhagic Fever Virus

Citation Formats

References (122)

Cited By (16)

Similar Records

Related Subjects