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Construction and Evaluation of Novel Rhesus Monkey Adenovirus Vaccine Vectors

Journal Article · · Journal of Virology
DOI:https://doi.org/10.1128/JVI.02950-14· OSTI ID:1235731
 [1];  [1];  [1];  [1];  [1];  [1];  [1];  [1];  [1];  [2];  [3];  [3];  [3];  [4];  [5]
  1. Harvard Medical School, Boston, MA (United States)
  2. Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
  3. Washington Univ. School of Medicine, St. Louis, MO (United States)
  4. Los Alamos National Laboratory
  5. Harvard Medical School, Boston, MA (United States); Ragon Inst. of MGH, Boston, MA (United States)
+ Show Author Affiliations
Adenovirus vectors are widely used as vaccine candidates for a variety of pathogens, including HIV-1. To date, human and chimpanzee adenoviruses have been explored in detail as vaccine vectors. Furthermore, the phylogeny of human and chimpanzee adenoviruses is overlapping, and preexisting humoral and cellular immunity to both are exhibited in human populations worldwide. More distantly related adenoviruses may therefore offer advantages as vaccine vectors. We describe the primary isolation and vectorization of three novel adenoviruses from rhesus monkeys. The seroprevalence of these novel rhesus monkey adenovirus vectors was extremely low in sub-Saharan Africa human populations, and these vectors proved to have immunogenicity comparable to that of human and chimpanzee adenovirus vaccine vectors in mice. These rhesus monkey adenoviruses phylogenetically clustered with the poorly described adenovirus species G and robustly stimulated innate immune responses. These novel adenoviruses represent a new class of candidate vaccine vectors.
Research Organization:
Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
Sponsoring Organization:
USDOE
Grant/Contract Number:
AC52-06NA25396
OSTI ID:
1235731
Report Number(s):
LA-UR--14-28201
Journal Information:
Journal of Virology, Journal Name: Journal of Virology Journal Issue: 3 Vol. 89; ISSN 0022-538X
Country of Publication:
United States
Language:
English

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Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys journal August 2016
The Coxsackievirus and Adenovirus Receptor, a Required Host Factor for Recovirus Infection, Is a Putative Enteric Calicivirus Receptor journal September 2019
Comparative Evaluation of the Vaccine Efficacies of Three Adenovirus-Based Vector Types in the Friend Retrovirus Infection Model journal August 2019
Recombinant Chimpanzee Adenovirus Vaccine AdC7-M/E Protects against Zika Virus Infection and Testis Damage journal January 2018
Therapeutic Efficacy of Vectored PGT121 Gene Delivery in HIV-1-Infected Humanized Mice journal January 2018
Development of Zika Virus Vaccines journal January 2018

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