Lipidomic Analysis of Endocannabinoid Signaling: Targeted Metabolite Identification and Quantification

Keereetaweep, Jantana; Chapman, Kent D.

doi:10.1155/2016/2426398

Title: Lipidomic Analysis of Endocannabinoid Signaling: Targeted Metabolite Identification and Quantification

Journal Article · Fri Jan 01 00:00:00 EST 2016 · Neural Plasticity

DOI:https://doi.org/10.1155/2016/2426398· OSTI ID:1234050

Keereetaweep, Jantana ^[1]; Chapman, Kent D. ^[2]

Department of Biological Sciences, Center for Plant Lipid Research, University of North Texas, Denton, TX 76203, USA, Brookhaven National Laboratory, 50 Bell Avenue, Building 463, P.O. Box 5000, Upton, NY 11973-5000, USA
Department of Biological Sciences, Center for Plant Lipid Research, University of North Texas, Denton, TX 76203, USA

The endocannabinoidsN-arachidonoylethanolamide (or anandamide, AEA) and 2-arachidonoylglycerol (2-AG) belong to the larger groups ofN-acylethanolamines (NAEs) and monoacylglycerol (MAG) lipid classes, respectively. They are biologically active lipid molecules that activate G-protein-coupled cannabinoid receptors found in various organisms. After AEA and 2-AG were discovered in the 1990s, they have been extensively documented to have a broad range of physiological functions. Along with AEA, several NAEs, for example,N-palmitoylethanolamine (PEA),N-stearoylethanolamine (SEA), andN-oleoylethanolamine (OEA) are also present in tissues, usually at much larger concentrations than AEA. Any perturbation that involves the endocannabinoid pathway may subsequently alter basal level or metabolism of these lipid mediators. Further, the altered levels of these molecules often reflect pathological conditions associated with tissue damage. Robust and sensitive methodologies to analyze these lipid mediators are essential to understanding how they act as endocannabinoids. In conclusion, the recent advances in mass spectrometry allow researchers to develop lipidomics approaches and several methodologies have been proposed to quantify endocannabinoids in various biological systems.

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Research Organization:: Brookhaven National Laboratory (BNL), Upton, NY (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: FG02-05ER15647; SC00112704; FG02- 05ER15647

OSTI ID:: 1234050

Alternate ID(s):: OSTI ID: 1263472; OSTI ID: 1335430

Report Number(s):: BNL-112088-2016-JA; PII: 2426398; 2426398

Journal Information:: Neural Plasticity, Journal Name: Neural Plasticity Vol. 2016; ISSN 2090-5904

Publisher:: Hindawi Publishing CorporationCopyright Statement

Country of Publication:: Egypt

Language:: English

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Cited by: 17 works

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Title: Lipidomic Analysis of Endocannabinoid Signaling: Targeted Metabolite Identification and Quantification

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