Structure-Based Evaluation of Non-nucleoside Inhibitors with Improved Potency and Solubility That Target HIV Reverse Transcriptase Variants
Journal Article
·
· Journal of Medicinal Chemistry
- Research Organization:
- Brookhaven National Lab. (BNL), Upton, NY (United States)
- Sponsoring Organization:
- USDOE Office of Science (SC), Basic Energy Sciences (BES)
- DOE Contract Number:
- SC00112704
- OSTI ID:
- 1229411
- Report Number(s):
- BNL-111487-2015-JA
- Journal Information:
- Journal of Medicinal Chemistry, Vol. 58, Issue 6; ISSN 0022-2623
- Publisher:
- American Chemical Society (ACS)
- Country of Publication:
- United States
- Language:
- English
Similar Records
ROLES OF CONFORMATIONAL AND POSITIONAL ADAPTABILITY IN STRUCTURE-BASED DESIGN OF TMC125-R165335 (ETRAVIRINE)AND RELATED NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS THAT ARE HIGHLY POTENT AND EFFECTIVE AGAINST WILD-TYPE AND DRUG-RESISTANT HIV-1 VARIANT
Discovery of 3-{5-[(6-Amino-1H-pyrazolo[3,4-b]pyridine-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile (MK-4965): A Potent, Orally Bioavailable HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor with Improved Potency against Key Mutant Viruses
Structural and pharmacological evaluation of a novel non-nucleoside reverse transcriptase inhibitor as a promising long acting nanoformulation for treating HIV
Journal Article
·
Thu Jan 01 00:00:00 EST 2004
· BIOCHEMISTRY
·
OSTI ID:1229411
+6 more
Discovery of 3-{5-[(6-Amino-1H-pyrazolo[3,4-b]pyridine-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile (MK-4965): A Potent, Orally Bioavailable HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor with Improved Potency against Key Mutant Viruses
Journal Article
·
Fri Jul 10 00:00:00 EDT 2009
· J. Med. Chem.
·
OSTI ID:1229411
+18 more
Structural and pharmacological evaluation of a novel non-nucleoside reverse transcriptase inhibitor as a promising long acting nanoformulation for treating HIV
Journal Article
·
Fri Apr 26 00:00:00 EDT 2019
· Antiviral Research
·
OSTI ID:1229411
+9 more