Structural and pharmacological evaluation of a novel non-nucleoside reverse transcriptase inhibitor as a promising long acting nanoformulation for treating HIV

Kudalkar, Shalley N.; Ullah, Irfan; Bertoletti, Nicole; Mandl, Hanna K.; Cisneros, José A.; Beloor, Jagadish; Chan, Albert H.; Quijano, Elias; Saltzman, W. Mark; Jorgensen, William L.; Kumar, Priti; Anderson, Karen S.

doi:10.1016/j.antiviral.2019.04.010

Title: Structural and pharmacological evaluation of a novel non-nucleoside reverse transcriptase inhibitor as a promising long acting nanoformulation for treating HIV

Journal Article · Fri Apr 26 00:00:00 EDT 2019 · Antiviral Research

DOI:https://doi.org/10.1016/j.antiviral.2019.04.010· OSTI ID:1547408

Kudalkar, Shalley N. ^[1]; Ullah, Irfan ^[1]; Bertoletti, Nicole ^[1]; Mandl, Hanna K. ^[1]; Cisneros, José A. ^[1]; Beloor, Jagadish ^[1]; Chan, Albert H. ^[1]; Quijano, Elias ^[1]; Saltzman, W. Mark ^[1]; Jorgensen, William L. ^[1]; Kumar, Priti ^[1]; Anderson, Karen S. ^[1]

Yale Univ., New Haven, CT (United States)

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Research Organization:: Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: USDOE; National Institutes of Health (NIH)

Grant/Contract Number:: AC02-06CH11357; AI044616; GM049551; AI141172; AI112443; AI122384; EB000487; S10OD021527; P30 GM124165

OSTI ID:: 1547408

Alternate ID(s):: OSTI ID: 1636807

Journal Information:: Antiviral Research, Vol. 167, Issue 07, 2019; ISSN 0166-3542

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: ENGLISH

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Cited by: 12 works

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Structural insights into the recognition of nucleoside reverse transcriptase inhibitors by HIV‐1 reverse transcriptase: First crystal structures with reverse transcriptase and the active triphosphate forms of lamivudine and emtricitabine Bertoletti, Nicole; Chan, Albert H.; Schinazi, Raymond F. Protein Science https://doi.org/10.1002/pro.3681	journal	August 2019

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60 APPLIED LIFE SCIENCES
HIV-1
non-nucleoside reverse transcriptase inhibitor
long-acting nanoformulation
pharmacokinetic studies
mice model
x-ray crystallography

Title: Structural and pharmacological evaluation of a novel non-nucleoside reverse transcriptase inhibitor as a promising long acting nanoformulation for treating HIV

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