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Title: Compositions containing nucleosides and manganese and their uses

Abstract

This invention encompasses methods of preserving protein function by contacting a protein with a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese). In addition, the invention encompasses methods of treating and/or preventing a side effect of radiation exposure and methods of preventing a side effect of radiotherapy comprising administration of a pharmaceutically effective amount of a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese) to a subject in need thereof. The compositions may comprise D. radiodurans extracts.

Inventors:
; ; ; ;
Publication Date:
Research Org.:
The Henry M. Jackson Foundation for Advancement of Military Medicine, Inc., Bethesda, MD (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1226548
Patent Number(s):
9,186,406
Application Number:
12/673,709
Assignee:
The Henry M. Jackson Foundation for Advancement of Military Medicine, Inc. (Bethesda, MD) CHO
DOE Contract Number:  
FG02-04ER63918
Resource Type:
Patent
Resource Relation:
Patent File Date: 2008 Aug 18
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Daly, Michael J., Gaidamakova, Elena K., Matrosova, Vera Y., Levine, Rodney L., and Wehr, Nancy B.. Compositions containing nucleosides and manganese and their uses. United States: N. p., 2015. Web.
Daly, Michael J., Gaidamakova, Elena K., Matrosova, Vera Y., Levine, Rodney L., & Wehr, Nancy B.. Compositions containing nucleosides and manganese and their uses. United States.
Daly, Michael J., Gaidamakova, Elena K., Matrosova, Vera Y., Levine, Rodney L., and Wehr, Nancy B.. Tue . "Compositions containing nucleosides and manganese and their uses". United States. doi:. https://www.osti.gov/servlets/purl/1226548.
@article{osti_1226548,
title = {Compositions containing nucleosides and manganese and their uses},
author = {Daly, Michael J. and Gaidamakova, Elena K. and Matrosova, Vera Y. and Levine, Rodney L. and Wehr, Nancy B.},
abstractNote = {This invention encompasses methods of preserving protein function by contacting a protein with a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese). In addition, the invention encompasses methods of treating and/or preventing a side effect of radiation exposure and methods of preventing a side effect of radiotherapy comprising administration of a pharmaceutically effective amount of a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese) to a subject in need thereof. The compositions may comprise D. radiodurans extracts.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Nov 17 00:00:00 EST 2015},
month = {Tue Nov 17 00:00:00 EST 2015}
}

Patent:

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Works referenced in this record:

Protein Oxidation Implicated as the Primary Determinant of Bacterial Radioresistance
journal, March 2007

  • Daly, Michael J.; Gaidamakova, Elena K.; Matrosova, Vera Y.
  • PLoS Biology, Vol. 5, Issue 4, Article No. e92
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Accumulation of Mn(II) in Deinococcus radiodurans Facilitates Gamma-Radiation Resistance
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Small-Molecule Antioxidant Proteome-Shields in Deinococcus radiodurans
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Preserving Immunogenicity of Lethally Irradiated Viral and Bacterial Vaccine Epitopes Using a Radio- Protective Mn2+-Peptide Complex from Deinococcus
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A Manganese Porphyrin Complex is a Novel Radiation Protector
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