Chirality-selected phase behaviour in ionic polypeptide complexes

Perry, Sarah L.; Leon, Lorraine; Hoffmann, Kyle Q.; Kade, Matthew J.; Priftis, Dimitrios; Black, Katie A.; Wong, Derek; Klein, Ryan A.; Pierce, III, Charles F.; Margossian, Khatcher O.; Whitmer, Jonathan K.; Qin, Jian; de Pablo, Juan J.; Tirrell, Matthew

doi:10.1038/ncomms7052

Title: Chirality-selected phase behaviour in ionic polypeptide complexes

Journal Article · Wed Jan 14 00:00:00 EST 2015 · Nature Communications

DOI:https://doi.org/10.1038/ncomms7052· OSTI ID:1225228

Perry, Sarah L. ^[1]; Leon, Lorraine ^[2]; Hoffmann, Kyle Q. ^[3]; Kade, Matthew J. ^[2]; Priftis, Dimitrios ^[1]; Black, Katie A. ^[4]; Wong, Derek ^[1]; Klein, Ryan A. ^[1]; Pierce, III, Charles F. ^[1]; Margossian, Khatcher O. ^[1]; Whitmer, Jonathan K. ^[2]; Qin, Jian ^[1]; de Pablo, Juan J. ^[2]; Tirrell, Matthew ^[2]

Univ. of Chicago, Chicago, IL (United States)
Univ. of Chicago, Chicago, IL (United States); Argonne National Lab. (ANL), Argonne, IL (United States)
Univ. of Chicago, Chicago, IL (United States); Univ. of Wisconsin, Madison, WI (United States)
Univ. of California at Berkeley, Berkeley, CA (United States)

Polyelectrolyte complexes present new opportunities for self-assembled soft matter. Factors determining whether the phase of the complex is solid or liquid remain unclear. Ionic polypeptides enable examination of the effects of stereochemistry on complex formation. Here we demonstrate that chirality determines the state of polyelectrolyte complexes, formed from mixing dilute solutions of oppositely charged polypeptides, via a combination of electrostatic and hydrogen-bonding interactions. Fluid complexes occur when at least one of the polypeptides in the mixture is racemic, which disrupts backbone hydrogen-bonding networks. Pairs of purely chiral polypeptides, of any sense, form compact, fibrillar solids with a beta-sheet structure. Analogous behaviour occurs in micelles formed from polypeptide block copolymers with polyethylene oxide, where assembly into aggregates with either solid or fluid cores, and eventually into ordered phases at high concentrations, is possible. Chirality is an exploitable tool for manipulating material properties in polyelectrolyte complexation.

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Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES); Materials Sciences and Engineering Division

Grant/Contract Number:: AC02-06CH11357

OSTI ID:: 1225228

Alternate ID(s):: OSTI ID: 1352851

Journal Information:: Nature Communications, Vol. 6; ISSN 2041-1723

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 206 works

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