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Title: Systems and methods for laser assisted sample transfer to solution for chemical analysis

Patent ·
OSTI ID:1221973

Systems and methods are described for laser ablation of an analyte from a specimen and capturing of the analyte in a dispensed solvent to form a testing solution. A solvent dispensing and extraction system can form a liquid microjunction with the specimen. The solvent dispensing and extraction system can include a surface sampling probe. The laser beam can be directed through the surface sampling probe. The surface sampling probe can also serve as an atomic force microscopy probe. The surface sampling probe can form a seal with the specimen. The testing solution including the analyte can then be analyzed using an analytical instrument or undergo further processing.

Research Organization:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC05-00OR22725
Assignee:
UT-Battelle, LLC (Oak Ridge, TN)
Patent Number(s):
9,146,180
Application Number:
14/267,482
OSTI ID:
1221973
Resource Relation:
Patent File Date: 2014 May 01
Country of Publication:
United States
Language:
English

References (84)

Disposable beverage container patent February 1988
Composite analyzer tester patent May 1988
Disposable combination cup and base patent September 1989
Recyclable corrugated beverage container and holder patent April 1993
Method for selective removal of a material from a wafer's alignment marks patent December 1993
Method and apparatus for maldi analysis patent July 1998
Method and apparatus for the quantitative measurement of the corrosivity effect of residues present on the surface of electronic circuit assemblies patent July 1998
System and method for on-line coupling of liquid capillary separations with matrix-assisted laser desorption/ionization mass spectrometry patent October 2000
Method and apparatus for etch of a specific subarea of a semiconductor work object patent September 2001
Protein crystallization in microfluidic structures patent June 2002
Miniaturized fluid transfer device patent November 2002
Ultra high throughput sampling and analysis systems and methods patent September 2003
Sampling probe for microarray read out using electrospray mass spectrometry patent October 2004
Interface members and holders for microfluidic array devices patent March 2005
Nanotipped device and method patent July 2007
Detection of malaria parasites by mass spectrometry patent September 2007
Method for locally highly resolved, mass-spectroscopic characterization of surfaces using scanning probe technology patent October 2008
Methods for mass spectrometry detection and quantification of specific target proteins in complex biological samples patent November 2008
Laser desorption—electrospray ion (ESI) source for mass spectrometers patent April 2009
Acoustic desorption mass spectrometry patent January 2010
Mass spectroscopic reaction-monitoring method patent May 2010
Methods and apparatus for ink delivery to nanolithographic probe systems patent July 2010
Mass spectrometry with laser ablation patent March 2011
Laser ablation electrospray ionization (LAESI) for atmospheric pressure, In vivo, and imaging mass spectrometry patent November 2011
Focused analyte spray emission apparatus and process for mass spectrometric analysis patent January 2012
Systems and methods for laser assisted sample transfer to solution for chemical analysis patent August 2013
System and method for laser assisted sample transfer to solution for chemical analysis patent January 2014
Ionization device, mass spectrometer including the ionization device, and image generation system including the ionization device patent April 2014
Systems and methods for laser assisted sample transfer to solution for chemical analysis patent June 2014
Variable resistance memory devices patent June 2014
Ionization apparatus, mass spectrometer including ionization apparatus, and image forming system patent February 2015
Method and apparatus for maldi analysis patent-application August 2002
Direct flow injection analysis nebulization electrospray and APCI mass spectrometry patent-application November 2002
Sampling probe for microarray read out using electrospray mass spectrometry patent-application October 2003
Method and apparatus for continuous sample deposition on sample support plates for liquid chromatography-matrix-assisted laser desorption/ionization mass spectrometry patent-application February 2004
Scanning probe microscopy probe and method for scanning probe contact printing patent-application November 2004
Methods and devices for concentration and purification of analytes for chemical analysis including matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS) patent-application June 2005
Methods and compositions for assessing a sample by maldi mass spectrometry patent-application August 2005
Container and method of making a container patent-application December 2005
Multi-function laser induced breakdown spectroscopy and laser ablation material analysis system and method patent-application March 2007
Automated Analysis Of Complex Matrices Using Mass Spectrometer patent-application June 2007
Means and method for analyzing samples by mass spectrometry patent-application September 2007
Quantitative Analysis of Surface-Derived Samples using Mass Spectrometry patent-application November 2007
High power laser induced acoustic desorption probe patent-application December 2007
Mass Spectrometry With Laser Ablation patent-application June 2008
Apparatus and method for isolating a nucleic acid from a sample patent-application June 2008
Laser desorption - electrospray ion (ESI) source for mass spectrometers patent-application November 2008
Electrospray-Assisted Laser-Induced Acoustic Desorption Ionization Mass Spectrometer and a Method for Mass Spectrometry patent-application December 2008
Device for Processing a Biological And/or Chemical Sample and Method of Using the Same patent-application February 2009
Increasing Ionization Efficiency in Mass Spectroscopy patent-application May 2009
Differential Hemolysis of a Whole Blood Sample patent-application October 2009
Disposable Containers and Utensils for Sanitizing patent-application October 2009
Laser Ablation Electrospray Ionization (LAESI) for Atmospheric Pressure, In Vivo, and Imaging Mass Spectrometry patent-application November 2009
Method of Preparing Sample for Matrix-Assisted Laser Desorption Ionization Mass Spectrometry and Matrix-Assisted Laser Desorption Ionization Mass Spectrometry patent-application February 2010
Method and system for formation and withdrawal of a sample from a surface to be analyzed patent-application September 2010
Solid-Phase Extraction (SPE) Tips and Methods of Use patent-application June 2011
Cycling Electrospray Ionization Device patent-application September 2011
Beverage Pod patent-application October 2011
Laser-Induced Acoustic Desorption/ Atmospheric Pressure Chemical Ionization of Compounds patent-application November 2011
Spatially resolved thermal desorption/ionization coupled with mass spectrometry patent-application March 2012
Surface Sampling Concentration and Reaction Probe patent-application April 2012
Ion Generation Using Wetted Porous Material patent-application May 2012
Nanodispenser for attoliter volume deposition using atomic force microscopy probes modified by focused-ion-beam milling journal December 2004
Evidence of near-field laser ablation inductively coupled plasma mass spectrometry (NF-LA-ICP-MS) at nanometre scale for elemental and isotopic analysis on gels and biological samples journal January 2006
Field enhancement in apertureless near-field scanning optical microscopy journal January 2001
The irradiation effect of a Nd–YAG pulsed laser on the CeO2 target in the liquid journal January 2004
Looking at the nanoscale: scanning near-field optical microscopy journal February 2003
Laser Ablation of a Sample In Liquid—LASIL journal January 2011
Near-Field Scanning Optical Microscopy journal October 1999
Apertureless Metallic Probes for Near-Field Microscopy book January 2001
Transmission studies of explosive vaporization of a transparent liquid film on an opaque solid surface induced by excimer‐laser‐pulsed irradiation journal September 1992
Laser ablation in liquids as a new technique of sampling in elemental analysis of solid materials journal February 2009
Near-Field Optical Microscopy and Spectroscopy with Pointed Probes journal May 2006
Methods for Molecular Nanoanalysis journal November 2006
Towards Nanoscale Molecular Analysis at Atmospheric Pressure by a Near-Field Laser Ablation Ion Trap/Time-of-Flight Mass Spectrometer journal September 2008
Nanoscale Atmospheric Pressure Laser Ablation-Mass Spectrometry journal April 2001
Microsecond-resolved imaging of laser ablation at solid–liquid interface: investigation of formation process of nano-size metal colloids journal May 2004
Hollow nanoparticle generation on laser-induced cavitation bubbles via bubble interface pinning journal September 2010
Laser ablation in liquids: Applications in the synthesis of nanocrystals journal May 2007
Laser ablation in a liquid medium as a technique for solid sampling journal January 1991
Bubble nucleation and pressure generation during laser cleaning of surfaces journal April 1997
Optical reflectance and scattering studies of nucleation and growth of bubbles at a liquid-solid interface induced by pulsed laser heating journal March 1993
Pulsed laser‐induced desorption and optical imaging on a nanometer scale with scanning near‐field microscopy using chemically etched fiber tips journal April 1996
Possibility of nano-local element analysis by near-field laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS): New experimental arrangement and first application journal June 2008