Well-temperate phage: Optimal bet-hedging against local environmental collapses

Maslov, Sergei; Sneppen, Kim

doi:10.1038/srep10523

Title: Well-temperate phage: Optimal bet-hedging against local environmental collapses

Journal Article · Tue Jun 02 00:00:00 EDT 2015 · Scientific Reports

DOI:https://doi.org/10.1038/srep10523· OSTI ID:1213376

Maslov, Sergei ^[1]; Sneppen, Kim ^[2]

Brookhaven National Lab. (BNL), Upton, NY (United States)
Univ. of Copenhagen, Copenhagen (Denmark)

Upon infection of their bacterial hosts temperate phages must chose between lysogenic and lytic developmental strategies. Here we apply the game-theoretic bet-hedging strategy introduced by Kelly to derive the optimal lysogenic fraction of the total population of phages as a function of frequency and intensity of environmental downturns affecting the lytic subpopulation. “Well-temperate” phage from our title is characterized by the best long-term population growth rate. We show that it is realized when the lysogenization frequency is approximately equal to the probability of lytic population collapse. We further predict the existence of sharp boundaries in system’s environmental, ecological, and biophysical parameters separating the regions where this temperate strategy is optimal from those dominated by purely virulent or dormant (purely lysogenic) strategies. We show that the virulent strategy works best for phages with large diversity of hosts, and access to multiple independent environments reachable by diffusion. Conversely, progressively more temperate or even dormant strategies are favored in the environments, that are subject to frequent and severe temporal downturns.

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Research Organization:: Brookhaven National Laboratory (BNL), Upton, NY (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: SC00112704

OSTI ID:: 1213376

Report Number(s):: BNL-108254-2015-JA; R&D Project: PM-031; KP1601040

Journal Information:: Scientific Reports, Vol. 5, Issue 8; ISSN 2045-2322

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 43 works

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