Biomarkers of Radiosensitivity in A-Bomb Survivors Pregnant at the Time of Bombings in Hiroshima and Nagasaki

Journal Article · Sat Jan 01 00:00:00 EST 2011 · ISRN Obstetrics and Gynecology

DOI:https://doi.org/10.5402/2011/264978· OSTI ID:1198184

Miles, Edward F. ^[1]; Tatsukawa, Yoshimi ^[2]; Funamoto, Sachiyo ^[3]; Kamada, Naoko ^[3]; Nakashima, Eiji ^[3]; Kodama, Yoshiaki ^[4]; Seed, Thomas ^[5]; Kusonoki, Yoichiro ^[6]; Nakachi, Kei ^[6]; Fujiwara, Saeko ^[2]; Akahoshi, Masazumi ^[7]; Neriishi, Kazuo ^[2]

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1. Division of Radiation Oncology, Department of Radiology, Naval Medical Center Portsmouth, 620 John Paul Jones Circle, Portsmouth, VA 23314, USA
2. Department of Clinical Studies (Hiroshima), Radiation Effects Research Foundation (RERF), 5-2 Hijiyama Park, Minami-ku, Hiroshima City, Japan
3. Department of Statistics, RERF, 5-2 Hijiyama Park, Minami-ku, Hiroshima City, Japan
4. Department of Genetics, RERF, 5-2 Hijiyama Park, Minami-ku, Hiroshima City, Japan
5. Associate Chief of Research, RERF, 5-2 Hijiyama Park, Minami-ku, Hiroshima City, Japan
6. Department of Radiation Biology/Molecular Epidemiology, RERF, 5-2 Hijiyama Park, Minami-ku, Hiroshima City, Japan
7. Department of Clinical Studies (Nagasaki), RERF, 8-6 Nakagawa 1-chome, Nagasaki City, Japan

Purpose . There is evidence in the literature of increased maternal radiosensitivity during pregnancy. Materials and Methods . We tested this hypothesis using information from the atomic-bomb survivor cohort, that is, the Adult Health Study database at the Radiation Effects Research Foundation, which contains data from a cohort of women who were pregnant at the time of the bombings of Hiroshima and Nagasaki. Previous evaluation has demonstrated long-term radiation dose-response effects. Results/Conclusions . Data on approximately 250 women were available to assess dose-response rates for serum cholesterol, white blood cell count, erythrocyte sedimentation rate, and serum hemoglobin, and on approximately 85 women for stable chromosome aberrations, glycophorin A locus mutations, and naïve CD4 T-cell counts. Although there is no statistically significant evidence of increased radiosensitivity in pregnant women, the increased slope of the linear trend line in the third trimester with respect to stable chromosome aberrations is suggestive of an increased radiosensitivity.

• Sponsoring Organization: USDOE
• OSTI ID: 1198184
• Journal Information: ISRN Obstetrics and Gynecology, Journal Name: ISRN Obstetrics and Gynecology Vol. 2011; ISSN 2090-4436
• Publisher: Hindawi (International Scholarly Research Network)
• Country of Publication: Country unknown/Code not available
• Language: English