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Relationship between dose and chromosome aberrations in atomic bomb survivors, Hiroshima and Nagasaki (in Japanese and English)

Technical Report ·
OSTI ID:6096076
; ; ; ; ;
Radiation-induced chromosome aberrations were found to persist in cultured peripheral blood lymphocytes derived from Hiroshima and Nagasaki A-bomb survivors long after their radiation exposure. Earlier observations that the frequency of cells with chromosome aberrations increased in proportion with increasing dose in both cities were reconfirmed. However, in every dose group, the frequency of aberrant cells was consistently higher in Hiroshima than in Nagasaki. Results suggesteed that a higher neutron dose in Hiroshima than in Nagasaki may have been a major component contributing to the difference in dose response between the two cities. Among the types of chromosome aberrations so far identified, reciprocal translocations were observed to predominate, and they played an important role in determining the dose-aberration relationship. Furthermore, it was recognized that symmetric chromosome exchanges seem to be a useful index of late radiation effects on somatic cells in vivo.
Research Organization:
Radiation Effects Research Foundation, Nagasaki (Japan). Nagasaki Branch; Radiation Effects Research Foundation, Hiroshima (Japan)
OSTI ID:
6096076
Report Number(s):
RERF-TR-12-77
Country of Publication:
United States
Language:
Japanese and English

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Related Subjects

560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
A-BOMB SURVIVORS
ACUTE EXPOSURE
ACUTE IRRADIATION
ANIMAL CELLS
ASIA
BARYONS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHROMOSOMAL ABERRATIONS
COMPARATIVE EVALUATIONS
CONNECTIVE TISSUE CELLS
DATA
DATA FORMS
DELAYED RADIATION EFFECTS
DOSE-RESPONSE RELATIONSHIPS
ELEMENTARY PARTICLES
EXPERIMENTAL DATA
EXPLOSIONS
FERMIONS
HADRONS
HIROSHIMA
INFORMATION
IRRADIATION
ISOLATED VALUES
JAPAN
LEUKOCYTES
LYMPHOCYTES
MUTATIONS
NAGASAKI
NEUTRONS
NUCLEAR EXPLOSIONS
NUCLEONS
NUMERICAL DATA
RADIATION EFFECTS
RADIOINDUCTION
SOMATIC CELLS