Lipid-peptide-polymer conjugates and nanoparticles thereof
Patent
·
OSTI ID:1183465
The present invention provides a conjugate having a peptide with from about 10 to about 100 amino acids, wherein the peptide adopts a helical structure. The conjugate also includes a first polymer covalently linked to the peptide, and a hydrophobic moiety covalently linked to the N-terminus of the peptide, wherein the hydrophobic moiety comprises a second polymer or a lipid moiety. The present invention also provides helix bundles form by self-assembling the conjugates, and particles formed by self-assembling the helix bundles. Methods of preparing the helix bundles and particles are also provided.
- Research Organization:
- Argonne National Laboratory (ANL), Argonne, IL (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC02-05CH11231
- Assignee:
- Regents of the University of California (Oakland, CA)
- Patent Number(s):
- 9,044,514
- Application Number:
- 13/610,637
- OSTI ID:
- 1183465
- Country of Publication:
- United States
- Language:
- English
Similar Records
Bis-polymer lipid-peptide conjugates and nanoparticles thereof
Bis-polymer lipid-peptide conjugates and nanoparticles thereof
Supramolecular Assembly of Peptide Amphiphiles
Patent
·
Tue Apr 24 00:00:00 EDT 2018
·
OSTI ID:1183465
+1 more
Bis-polymer lipid-peptide conjugates and nanoparticles thereof
Patent
·
Tue Oct 20 00:00:00 EDT 2020
·
OSTI ID:1183465
+1 more
Supramolecular Assembly of Peptide Amphiphiles
Journal Article
·
Wed Sep 06 00:00:00 EDT 2017
· Accounts of Chemical Research
·
OSTI ID:1183465
+1 more