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Title: Lipid-peptide-polymer conjugates and nanoparticles thereof

Abstract

The present invention provides a conjugate having a peptide with from about 10 to about 100 amino acids, wherein the peptide adopts a helical structure. The conjugate also includes a first polymer covalently linked to the peptide, and a hydrophobic moiety covalently linked to the N-terminus of the peptide, wherein the hydrophobic moiety comprises a second polymer or a lipid moiety. The present invention also provides helix bundles form by self-assembling the conjugates, and particles formed by self-assembling the helix bundles. Methods of preparing the helix bundles and particles are also provided.

Inventors:
; ;
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1183465
Patent Number(s):
9,044,514
Application Number:
13/610,637
Assignee:
Regents of the University of California (Oakland, CA) CHO
DOE Contract Number:  
AC02-05CH11231
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES; 77 NANOSCIENCE AND NANOTECHNOLOGY

Citation Formats

Xu, Ting, Dong, He, and Shu, Jessica. Lipid-peptide-polymer conjugates and nanoparticles thereof. United States: N. p., 2015. Web.
Xu, Ting, Dong, He, & Shu, Jessica. Lipid-peptide-polymer conjugates and nanoparticles thereof. United States.
Xu, Ting, Dong, He, and Shu, Jessica. Tue . "Lipid-peptide-polymer conjugates and nanoparticles thereof". United States. doi:. https://www.osti.gov/servlets/purl/1183465.
@article{osti_1183465,
title = {Lipid-peptide-polymer conjugates and nanoparticles thereof},
author = {Xu, Ting and Dong, He and Shu, Jessica},
abstractNote = {The present invention provides a conjugate having a peptide with from about 10 to about 100 amino acids, wherein the peptide adopts a helical structure. The conjugate also includes a first polymer covalently linked to the peptide, and a hydrophobic moiety covalently linked to the N-terminus of the peptide, wherein the hydrophobic moiety comprises a second polymer or a lipid moiety. The present invention also provides helix bundles form by self-assembling the conjugates, and particles formed by self-assembling the helix bundles. Methods of preparing the helix bundles and particles are also provided.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jun 02 00:00:00 EDT 2015},
month = {Tue Jun 02 00:00:00 EDT 2015}
}

Patent:

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Works referenced in this record:

Water self-diffusion in nonionic surfactant solutions. Hydration and obstruction effects
journal, November 1983

  • Nilsson, Per Gunnar; Lindman, Bjoern
  • The Journal of Physical Chemistry, Vol. 87, Issue 23, p. 4756-4761
  • DOI: 10.1021/j100246a041