Compositions and methods comprising cellulase variants with reduced affinity to non-cellulosic materials

Cascao-Pereira, Luis G; Kaper, Thijs; Kelemen, Bradley R; Liu, Amy D

Compositions and methods comprising cellulase variants with reduced affinity to non-cellulosic materials

Patent · 07 April 2015

OSTI ID:1177516

Cascao-Pereira, Luis G; Kaper, Thijs; Kelemen, Bradley R; Liu, Amy D

The present disclosure relates to cellulase variants. In particular the present disclosure relates to cellulase variants having reduced binding to non-cellulosic materials. Also described are nucleic acids encoding the cellulase, compositions comprising said cellulase, methods of identifying cellulose variants and methods of using the compositions.

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Research Organization:: Danisco US Inc., Palo Alto, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: FC36-08GO18078

Assignee:: Danisco US Inc. (Palo Alto, CA)

Patent Number(s):: 8,999,692

Application Number:: 13/543,627

OSTI ID:: 1177516

Country of Publication:: United States

Language:: English

References (16)

Purification and characterization of a β-glucosidase from solid-state cultures of Humicola grisea var. thermoidea Filho, Edivaldo Ximenes Ferreira Canadian Journal of Microbiology, Vol. 42, Issue 1, p. 1-5 https://doi.org/10.1139/m96-001	journal	January 1996
Studies of the cellulolytic system of Trichoderma reesei QM 9414. Analysis of domain function in two cellobiohydrolases by limited proteolysis TOMME, Peter; TILBEURGH, Herman; PETTERSSON, Goran European Journal of Biochemistry, Vol. 170, Issue 3, p. 575-581 https://doi.org/10.1111/j.1432-1033.1988.tb13736.x	journal	January 1988
The roles and function of cellulose-binding domains Linder, Markus; Teeri, Tuula T. Journal of Biotechnology, Vol. 57, Issue 1-3, p. 15-28 https://doi.org/10.1016/S0168-1656(97)00087-4	journal	September 1997
Cloning and relational analysis of 15 novel fungal endoglucanases from family 12 glycosyl hydrolase Goedegebuur, Frits; Fowler, Timothy; Phillips, Jay Current Genetics, Vol. 41, Issue 2, p. 89-98 https://doi.org/10.1007/s00294-002-0290-2	journal	May 2002
Dilute-Sulfuric Acid Pretreatment of Corn Stover in Pilot-Scale Reactor Schell, Daniel J.; Farmer, Jody; Newman, Millie Biotechnology for Fuels and Chemicals https://doi.org/10.1007/978-1-4612-0057-4_6	book	January 2003
Molecular cloning, transcriptional, and expression analysis of the first cellulase gene (cbh2), encoding cellobiohydrolase II, from the moderately thermophilic fungus Talaromyces emersonii and structure prediction of the gene product Murray, P. G.; Collins, C. M.; Grassick, A. Biochemical and Biophysical Research Communications, Vol. 301, Issue 2, p. 280-286 https://doi.org/10.1016/S0006-291X(02)03025-5	journal	February 2003
Isolation of uridine auxotrophs from Trichoderma reesei and efficient transformation with the cloned ura3 and ura5 genes Bergès, Thierry; Barreau, Christian Current Genetics, Vol. 19, Issue 5, p. 359-365 https://doi.org/10.1007/BF00309596	journal	May 1991
Characterization of the secreted cellulases of Trichoderma reesei wild type and mutants during controlled fermentations Sheir-Neiss, G.; Montenecourt, B. S. Applied Microbiology and Biotechnology, Vol. 20, Issue 1, p. 46-53 https://doi.org/10.1007/BF00254645	journal	July 1984
Limited proteolysis of the cellobiohydrolase I from Trichoderma reesei: Separation of functional domains Van Tilbeurgh, Herman; Tomme, Peter; Claeyssens, Marc FEBS Letters, Vol. 204, Issue 2, p. 223-227 https://doi.org/10.1016/0014-5793(86)80816-X	journal	August 1986
Homologous domains in Trichoderma reesei cellulolytic enzymes: Gene sequence and expression of cellobiohydrolase II Teeri, Tuula T.; Lehtovaara, Päivi; Kauppinen, Sakari Gene, Vol. 51, Issue 1, p. 43-52 https://doi.org/10.1016/0378-1119(87)90472-0	journal	January 1987
Molecular Biology of Cellulolytic Fungi Nevalainen, H.; Penttilä, M.; Kück, Ulrich Genetics and Biotechnology, p. 303-319 https://doi.org/10.1007/978-3-662-10364-7_18	book	January 1995
Crystallographic evidence for substrate ring distortion and protein conformational changes during catalysis in cellobiohydrolase Ce16A from Trichoderma reesei Zou, Jin-yu; Kleywegt, Gerard J.; Ståhlberg, Jerry Structure, Vol. 7, Issue 9, p. 1035-1045 https://doi.org/10.1016/S0969-2126(99)80171-3	journal	September 1999
Basic local alignment search tool Altschul, Stephen F.; Gish, Warren; Miller, Webb Journal of Molecular Biology, Vol. 215, Issue 3, p. 403-410 https://doi.org/10.1016/S0022-2836(05)80360-2	journal	October 1990
Cellulase families and their genes Knowles, Jonathan; Lehtovaara, Päivi; Teeri, Tuula Trends in Biotechnology, Vol. 5, Issue 9, p. 255-261 https://doi.org/10.1016/0167-7799(87)90102-8	journal	September 1987
Hydrolysis of Cellulose Using Ternary Mixtures of Purified Cellulases Baker, John O.; Ehrman, Christine I.; Adney, William S. Biotechnology for Fuels and Chemicals https://doi.org/10.1007/978-1-4612-1814-2_37	book	January 1998
Molecular Cloning of Exo–Cellobiohydrolase I Derived from Trichoderma Reesei Strain L27 Shoemaker, S.; Schweickart, V.; Ladner, M. Nature Biotechnology, Vol. 1, Issue 8, p. 691-696 https://doi.org/10.1038/nbt1083-691	journal	October 1983

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