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Title: Methods for attaching polymerizable ceragenins to water treatment membranes using amine and amide linkages

Abstract

This invention relates to methods for chemically grafting and attaching ceragenin molecules to polymer substrates; methods for synthesizing ceragenin-containing copolymers; methods for making ceragenin-modified water treatment membranes and spacers; and methods of treating contaminated water using ceragenin-modified treatment membranes and spacers. Ceragenins are synthetically produced antimicrobial peptide mimics that display broad-spectrum bactericidal activity. Alkene-functionalized ceragenins (e.g., acrylamide-functionalized ceragenins) can be attached to polyamide reverse osmosis membranes using amine-linking, amide-linking, UV-grafting, or silane-coating methods. In addition, silane-functionalized ceragenins can be directly attached to polymer surfaces that have free hydroxyls.

Inventors:
; ; ;
Publication Date:
Research Org.:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1176511
Patent Number(s):
8,557,031
Application Number:
12/986,215
Assignee:
Sandia Corporation SNL-A
DOE Contract Number:  
AC04-94AL85000
Resource Type:
Patent
Resource Relation:
Patent File Date: 2011 Jan 07
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 60 APPLIED LIFE SCIENCES

Citation Formats

Hibbs, Michael, Altman, Susan J., Jones, Howland D.T., and Savage, Paul B. Methods for attaching polymerizable ceragenins to water treatment membranes using amine and amide linkages. United States: N. p., 2013. Web.
Hibbs, Michael, Altman, Susan J., Jones, Howland D.T., & Savage, Paul B. Methods for attaching polymerizable ceragenins to water treatment membranes using amine and amide linkages. United States.
Hibbs, Michael, Altman, Susan J., Jones, Howland D.T., and Savage, Paul B. Tue . "Methods for attaching polymerizable ceragenins to water treatment membranes using amine and amide linkages". United States. https://www.osti.gov/servlets/purl/1176511.
@article{osti_1176511,
title = {Methods for attaching polymerizable ceragenins to water treatment membranes using amine and amide linkages},
author = {Hibbs, Michael and Altman, Susan J. and Jones, Howland D.T. and Savage, Paul B.},
abstractNote = {This invention relates to methods for chemically grafting and attaching ceragenin molecules to polymer substrates; methods for synthesizing ceragenin-containing copolymers; methods for making ceragenin-modified water treatment membranes and spacers; and methods of treating contaminated water using ceragenin-modified treatment membranes and spacers. Ceragenins are synthetically produced antimicrobial peptide mimics that display broad-spectrum bactericidal activity. Alkene-functionalized ceragenins (e.g., acrylamide-functionalized ceragenins) can be attached to polyamide reverse osmosis membranes using amine-linking, amide-linking, UV-grafting, or silane-coating methods. In addition, silane-functionalized ceragenins can be directly attached to polymer surfaces that have free hydroxyls.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2013},
month = {10}
}

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