Methods for attaching polymerizable ceragenins to water treatment membranes using amine and amide linkages

Hibbs, Michael; Altman, Susan J.; Jones, Howland D.T.; Savage, Paul B.

Methods for attaching polymerizable ceragenins to water treatment membranes using amine and amide linkages

Patent · Tue Oct 15 04:00:00 EDT 2013

OSTI ID:1176511

Hibbs, Michael; Altman, Susan J.; Jones, Howland D.T.; Savage, Paul B.

This invention relates to methods for chemically grafting and attaching ceragenin molecules to polymer substrates; methods for synthesizing ceragenin-containing copolymers; methods for making ceragenin-modified water treatment membranes and spacers; and methods of treating contaminated water using ceragenin-modified treatment membranes and spacers. Ceragenins are synthetically produced antimicrobial peptide mimics that display broad-spectrum bactericidal activity. Alkene-functionalized ceragenins (e.g., acrylamide-functionalized ceragenins) can be attached to polyamide reverse osmosis membranes using amine-linking, amide-linking, UV-grafting, or silane-coating methods. In addition, silane-functionalized ceragenins can be directly attached to polymer surfaces that have free hydroxyls.

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Research Organization:: Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC04-94AL85000

Assignee:: Sandia Corporation

Patent Number(s):: 8,557,031

Application Number:: 12/986,215

OSTI ID:: 1176511

Country of Publication:: United States

Language:: English

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