Biofouling-resistant ceragenin-modified materials and structures for water treatment

Hibbs, Michael; Altman, Susan J.; Jones, Howland D. T.; Savage, Paul B.

Biofouling-resistant ceragenin-modified materials and structures for water treatment

Patent · Tue Sep 10 00:00:00 EDT 2013

OSTI ID:1092910

Hibbs, Michael; Altman, Susan J.; Jones, Howland D. T.; Savage, Paul B.

This invention relates to methods for chemically grafting and attaching ceragenin molecules to polymer substrates; methods for synthesizing ceragenin-containing copolymers; methods for making ceragenin-modified water treatment membranes and spacers; and methods of treating contaminated water using ceragenin-modified treatment membranes and spacers. Ceragenins are synthetically produced antimicrobial peptide mimics that display broad-spectrum bactericidal activity. Alkene-functionalized ceragenins (e.g., acrylamide-functionalized ceragenins) can be attached to polyamide reverse osmosis membranes using amine-linking, amide-linking, UV-grafting, or silane-coating methods. In addition, silane-functionalized ceragenins can be directly attached to polymer surfaces that have free hydroxyls.

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Research Organization:: SNL-A (Sandia National Laboratories, Albuquerque, NM (United States))

Sponsoring Organization:: USDOE

DOE Contract Number:: AC04-94AL85000

Assignee:: Sandia Corporation (Albuquerque, NM)

Patent Number(s):: 8,529,681

Application Number:: 12/986,234

OSTI ID:: 1092910

Country of Publication:: United States

Language:: English

References (14)

Promoting the cytocompatibility of polyurethane scaffolds via surface photo-grafting polymerization of acrylamide Zhu, Yabin; Gao, Changyou; Guan, Jianjun Journal of Materials Science: Materials in Medicine, Vol. 15, Issue 3 https://doi.org/10.1023/B:JMSM.0000015489.27261.f0	journal	March 2004
Polyacrylamide brush coatings preventing microbial adhesion to silicone rubber Fundeanu, Irina; van der Mei, Henny C.; Schouten, Arend J. Colloids and Surfaces B: Biointerfaces, Vol. 64, Issue 2 https://doi.org/10.1016/j.colsurfb.2008.02.005	journal	July 2008
Fouling of Reverse Osmosis and Ultrafiltration Membranes: A Critical Review Goosen, M. F. A.; Sablani, S. S.; Al‐Hinai, H. Separation Science and Technology, Vol. 39, Issue 10 https://doi.org/10.1081/SS-120039343	journal	January 2005
Surface modification of commercial composite polyamide reverse osmosis membranes Belfer, S.; Purinson, Y.; Fainshtein, R. Journal of Membrane Science, Vol. 139, Issue 2 https://doi.org/10.1016/S0376-7388(97)00248-2	journal	February 1998
Correlation of the Antibacterial Activities of Cationic Peptide Antibiotics and Cationic Steroid Antibiotics Ding, Bangwei; Guan, Qunying; Walsh, Joshua P. Journal of Medicinal Chemistry, Vol. 45, Issue 3 https://doi.org/10.1021/jm0105070	journal	December 2001
Characterization of isolated polyamide thin films of RO and NF membranes using novel TEM techniques Pacheco, Federico A.; Pinnau, Ingo; Reinhard, Martin Journal of Membrane Science, Vol. 358, Issue 1-2 https://doi.org/10.1016/j.memsci.2010.04.032	journal	August 2010
Antibacterial Activities of Thin Films Containing Ceragenins Savage, Paul B.; Nielsen, Jason; Lai, Xin-Zhong ACS Symposium Series https://doi.org/10.1021/bk-2008-0984.ch005	book	May 2008
Photoinduced graft polymerization of acrylamide on polypropylene microporous membranes for the improvement of antifouling characteristics in a submerged membrane-bioreactor Yu, H.; Xu, Z.; Lei, H. Separation and Purification Technology, Vol. 53, Issue 1 https://doi.org/10.1016/j.seppur.2006.07.002	journal	February 2007
Ceragenins: Cholic Acid-Based Mimics of Antimicrobial Peptides Lai, Xin-Zhong; Feng, Yanshu; Pollard, Jacob Accounts of Chemical Research, Vol. 41, Issue 10 https://doi.org/10.1021/ar700270t	journal	July 2008
Peptide Antimicrobial Agents Jenssen, Håvard; Hamill, Pamela; Hancock, Robert E. W. Clinical Microbiology Reviews, Vol. 19, Issue 3 https://doi.org/10.1128/CMR.00056-05	journal	July 2006
Origins of Cell Selectivity of Cationic Steroid Antibiotics Ding, Bangwei; Yin, Ning; Liu, Yang Journal of the American Chemical Society, Vol. 126, Issue 42 https://doi.org/10.1021/ja046909p	journal	October 2004
Synthesis and Characterization of Surface-Grafted Polyacrylamide Brushes and Their Inhibition of Microbial Adhesion Cringus-Fundeanu, Irina; Luijten, Jeroen; van der Mei, Henny C. Langmuir, Vol. 23, Issue 9 https://doi.org/10.1021/la063531v	journal	March 2007
Cationic Steroid Antibiotics Savage, P. Current Medicinal Chemistry -Anti-Infective Agents, Vol. 1, Issue 3 https://doi.org/10.2174/1568012023354776	journal	July 2002
Synthesis and Characterization of Peptide−Cationic Steroid Antibiotic Conjugates Ding, Bangwei; Taotofa, Uale; Orsak, Thomas Organic Letters, Vol. 6, Issue 20 https://doi.org/10.1021/ol048845t	journal	September 2004

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