Compositions and methods involving methyladenosine phosphorylase in the diagnosis and treatment of proliferative disorders

Olopade, Olufunmilayo I.

Title: Compositions and methods involving methyladenosine phosphorylase in the diagnosis and treatment of proliferative disorders

Patent · Tue Mar 20 00:00:00 EDT 2007

OSTI ID:1176153

Olopade, Olufunmilayo I.

Disclosed are novel nucleic acid and peptide compositions comprising methylthioadenosine phosphorylase (MTAP) and methods of use for MTAP amino acid sequences and DNA segments comprising MTAP in the diagnosis of human cancers and development of MTAP-specific antibodies. Also disclosed are methods for the diagnosis and treatment of tumors and other proliferative cell disorders, and identification of tumor suppressor genes and gene products from the human 9p21-p22 chromosome region. Such methods are useful in the diagnosis of multiple tumor types such as bladder cancer, lung cancer, breast cancer, pancreatic cancer, brain tumors, lymphomas, gliomas, melanomas, and leukemias.

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Research Organization:: Arch Development Corporation, Chicago, IL (United States)

Sponsoring Organization:: USDOE; National Cancer Institute (NCI); US Public Health Service

DOE Contract Number:: FG02-86ER60408; CA14599-19; CA40046; CA42557

Assignee:: Arch Development Corporation (Chicago, IL)

Patent Number(s):: 7,192,711

Application Number:: 11/087,072

OSTI ID:: 1176153

Resource Relation:: Patent File Date: 2005 Mar 22

Country of Publication:: United States

Language:: English

References (31)

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