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Title: Compositions and methods involving methyladenosine phosphorylase in the diagnosis and treatment of proliferative disorders

Abstract

Disclosed are novel nucleic acid and peptide compositions comprising methylthioadenosine phosphorylase (MTAP) and methods of use for MTAP amino acid sequences and DNA segments comprising MTAP in the diagnosis of human cancers and development of MTAP-specific antibodies. Also disclosed are methods for the diagnosis and treatment of tumors and other proliferative cell disorders, and identification of tumor suppressor genes and gene products from the human 9p21-p22 chromosome region. Such methods are useful in the diagnosis of multiple tumor types such as bladder cancer, lung cancer, breast cancer, pancreatic cancer, brain tumors, lymphomas, gliomas, melanomas, and leukemias.

Inventors:
Publication Date:
Research Org.:
Arch Development Corporation, Chicago, IL (United States)
Sponsoring Org.:
USDOE; National Cancer Institute (NCI); US Public Health Service
OSTI Identifier:
1176153
Patent Number(s):
7,192,711
Application Number:
11/087,072
Assignee:
Arch Development Corporation (Chicago, IL)
DOE Contract Number:  
FG02-86ER60408; CA14599-19; CA40046; CA42557
Resource Type:
Patent
Resource Relation:
Patent File Date: 2005 Mar 22
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; 59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Olopade, Olufunmilayo I. Compositions and methods involving methyladenosine phosphorylase in the diagnosis and treatment of proliferative disorders. United States: N. p., 2007. Web.
Olopade, Olufunmilayo I. Compositions and methods involving methyladenosine phosphorylase in the diagnosis and treatment of proliferative disorders. United States.
Olopade, Olufunmilayo I. 2007. "Compositions and methods involving methyladenosine phosphorylase in the diagnosis and treatment of proliferative disorders". United States. https://www.osti.gov/servlets/purl/1176153.
@article{osti_1176153,
title = {Compositions and methods involving methyladenosine phosphorylase in the diagnosis and treatment of proliferative disorders},
author = {Olopade, Olufunmilayo I.},
abstractNote = {Disclosed are novel nucleic acid and peptide compositions comprising methylthioadenosine phosphorylase (MTAP) and methods of use for MTAP amino acid sequences and DNA segments comprising MTAP in the diagnosis of human cancers and development of MTAP-specific antibodies. Also disclosed are methods for the diagnosis and treatment of tumors and other proliferative cell disorders, and identification of tumor suppressor genes and gene products from the human 9p21-p22 chromosome region. Such methods are useful in the diagnosis of multiple tumor types such as bladder cancer, lung cancer, breast cancer, pancreatic cancer, brain tumors, lymphomas, gliomas, melanomas, and leukemias.},
doi = {},
url = {https://www.osti.gov/biblio/1176153}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Mar 20 00:00:00 EDT 2007},
month = {Tue Mar 20 00:00:00 EDT 2007}
}

Works referenced in this record:

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