Zero-mode waveguides

Levene, Michael J.; Korlach, Jonas; Turner, Stephen W.; Craighead, Harold G.; Webb, Watt W.

Zero-mode waveguides

Patent · Tue Feb 20 04:00:00 EST 2007

OSTI ID:1176124

Levene, Michael J.; Korlach, Jonas; Turner, Stephen W.; Craighead, Harold G.; Webb, Watt W.

The present invention is directed to a method and an apparatus for analysis of an analyte. The method involves providing a zero-mode waveguide which includes a cladding surrounding a core where the cladding is configured to preclude propagation of electromagnetic energy of a frequency less than a cutoff frequency longitudinally through the core of the zero-mode waveguide. The analyte is positioned in the core of the zero-mode waveguide and is then subjected, in the core of the zero-mode waveguide, to activating electromagnetic radiation of a frequency less than the cut-off frequency under conditions effective to permit analysis of the analyte in an effective observation volume which is more compact than if the analysis were carried out in the absence of the zero-mode waveguide.

Research Organization:: Cornell Univ., Ithaca, NY (United States)

Sponsoring Organization:: USDOE; National Science Foundation (NSF); National Institutes of Health (NIH)

Assignee:: Cornell Research Foundation, Inc. (Ithaca, NY)

Patent Number(s):: 7,181,122

Application Number:: 11/313,971

OSTI ID:: 1176124

Country of Publication:: United States

Language:: English

References (9)

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Subwavelength surface-relief gratings fabricated by microcontact printing of self-assembled monolayers Lopez, Ali G.; Craighead, Harold G. Applied Optics, Vol. 40, Issue 13 https://doi.org/10.1364/AO.40.002068	journal	January 2001

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