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Waveguides for performing spectroscopy with confined effective observation volumes

Patent ·
OSTI ID:1175672
The present invention is directed to a method and an apparatus for analysis of an analyte. The method involves providing a zero-mode waveguide which includes a cladding surrounding a core where the cladding is configured to preclude propagation of electromagnetic energy of a frequency less than a cutoff frequency longitudinally through the core of the zero-mode waveguide. The analyte is positioned in the core of the zero-mode waveguide and is then subjected, in the core of the zero-mode waveguide, to activating electromagnetic radiation of a frequency less than the cut-off frequency under conditions effective to permit analysis of the analyte in an effective observation volume which is more compact than if the analysis were carried out in the absence of the zero-mode waveguide.
Research Organization:
Cornell Research Foundation, Inc., Ithaca, NY (United States)
Sponsoring Organization:
USDOE
Assignee:
Cornell Research Foundation, Inc. (Ithaca, NY)
Patent Number(s):
7,013,054
Application Number:
11/151,807
OSTI ID:
1175672
Country of Publication:
United States
Language:
English

References (3)

Nanoelectromechanical Systems journal November 2000
Fabrication of microcapillaries and waveguides for single-molecule detection conference March 1998
Subwavelength surface-relief gratings fabricated by microcontact printing of self-assembled monolayers journal January 2001

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