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Title: High throughput screening of ligand binding to macromolecules using high resolution powder diffraction

Abstract

A process is provided for the high throughput screening of binding of ligands to macromolecules using high resolution powder diffraction data including producing a first sample slurry of a selected polycrystalline macromolecule material and a solvent, producing a second sample slurry of a selected polycrystalline macromolecule material, one or more ligands and the solvent, obtaining a high resolution powder diffraction pattern on each of said first sample slurry and the second sample slurry, and, comparing the high resolution powder diffraction pattern of the first sample slurry and the high resolution powder diffraction pattern of the second sample slurry whereby a difference in the high resolution powder diffraction patterns of the first sample slurry and the second sample slurry provides a positive indication for the formation of a complex between the selected polycrystalline macromolecule material and at least one of the one or more ligands.

Inventors:
;
Publication Date:
Research Org.:
Los Alamos National Security, LLC, Los Alamos, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1175976
Patent Number(s):
7,130,747
Application Number:
09/871,527
Assignee:
Los Alamos National Security, LLC (Los Alamos, NM) LANL
DOE Contract Number:  
W-7405-ENG-36
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Von Dreele, Robert B., and D'Amico, Kevin. High throughput screening of ligand binding to macromolecules using high resolution powder diffraction. United States: N. p., 2006. Web.
Von Dreele, Robert B., & D'Amico, Kevin. High throughput screening of ligand binding to macromolecules using high resolution powder diffraction. United States.
Von Dreele, Robert B., and D'Amico, Kevin. Tue . "High throughput screening of ligand binding to macromolecules using high resolution powder diffraction". United States. https://www.osti.gov/servlets/purl/1175976.
@article{osti_1175976,
title = {High throughput screening of ligand binding to macromolecules using high resolution powder diffraction},
author = {Von Dreele, Robert B. and D'Amico, Kevin},
abstractNote = {A process is provided for the high throughput screening of binding of ligands to macromolecules using high resolution powder diffraction data including producing a first sample slurry of a selected polycrystalline macromolecule material and a solvent, producing a second sample slurry of a selected polycrystalline macromolecule material, one or more ligands and the solvent, obtaining a high resolution powder diffraction pattern on each of said first sample slurry and the second sample slurry, and, comparing the high resolution powder diffraction pattern of the first sample slurry and the high resolution powder diffraction pattern of the second sample slurry whereby a difference in the high resolution powder diffraction patterns of the first sample slurry and the second sample slurry provides a positive indication for the formation of a complex between the selected polycrystalline macromolecule material and at least one of the one or more ligands.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2006},
month = {10}
}

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