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Self-assembled lipid bilayer materials

Patent ·
OSTI ID:1175544
; ;
The present invention is a self-assembling material comprised of stacks of lipid bilayers formed in a columnar structure, where the assembly process is mediated and regulated by chemical recognition events. The material, through the chemical recognition interactions, has a self-regulating system that corrects the radial size of the assembly creating a uniform diameter throughout most of the structure. The materials form and are stable in aqueous solution. These materials are useful as structural elements for the architecture of materials and components in nanotechnology, efficient light harvesting systems for optical sensing, chemical processing centers, and drug delivery vehicles.
Research Organization:
Sandia National Laboratories (SNL-CA), Livermore, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC04-94AL85000;
Assignee:
Sandia Corporation
Patent Number(s):
6,962,747
Application Number:
10/041,846
OSTI ID:
1175544
Country of Publication:
United States
Language:
English

References (10)

Molecular Architecture and Function of Polymeric Oriented Systems: Models for the Study of Organization, Surface Recognition, and Dynamics of Biomembranes journal January 1988
Metal-Induced Dispersion of Lipid Aggregates: A Simple, Selective, and Sensitive Fluorescent Metal Ion Sensor journal May 1995
Self-Assembled Columns of Stacked Lipid Bilayers Mediated by Metal Ion Recognition journal January 2001
Engineering Protein-Lipid Interactions: Targeting of Histidine-Tagged Proteins to Metal-Chelating Lipid Monolayers journal October 1995
Dithioamide metal ion receptors on fluorescent lipid bilayers for the selective optical detection of mercuric ion journal January 1998
Reversible metal-directed assembly of clusters of vesicles journal January 1999
Optical detection of aqueous phase analytes via host-guest interactions on a lipid membrane surface conference June 1999
Structure of DNA-Cationic Liposome Complexes: DNA Intercalation in Multilamellar Membranes in Distinct Interhelical Packing Regimes journal February 1997
Hierarchical Self-Assembly of F-Actin and Cationic Lipid Complexes: Stacked Three-Layer Tubule Networks journal June 2000
Higher order self-assembly of vesicles by site-specific binding journal June 1994

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36 MATERIALS SCIENCE