Immobilized lipid-bilayer materials

Sasaki, Darryl Y; Loy, Douglas A; Yamanaka, Stacey A

Immobilized lipid-bilayer materials

Patent · Fri Dec 31 23:00:00 EST 1999

OSTI ID:872946

Sasaki, Darryl Y ^[1]; Loy, Douglas A ^[1]; Yamanaka, Stacey A ^[2]

Albuquerque, NM
Dallas, TX

A method for preparing encapsulated lipid-bilayer materials in a silica matrix comprising preparing a silica sol, mixing a lipid-bilayer material in the silica sol and allowing the mixture to gel to form the encapsulated lipid-bilayer material. The mild processing conditions allow quantitative entrapment of pre-formed lipid-bilayer materials without modification to the material's spectral characteristics. The method allows for the immobilization of lipid membranes to surfaces. The encapsulated lipid-bilayer materials perform as sensitive optical sensors for the detection of analytes such as heavy metal ions and can be used as drug delivery systems and as separation devices.

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Research Organization:: SANDIA CORP

DOE Contract Number:: AC04-94AL85000

Assignee:: Sandia Corporation (Albuquerque, NM)

Patent Number(s):: US 6048546

OSTI ID:: 872946

Country of Publication:: United States

Language:: English

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