Biosensor compositions and methods of use

Bayley, Hagan P.; Howorka, Stefan G.; Movileanu, Liviu

Title: Biosensor compositions and methods of use

Patent · Tue Jul 12 00:00:00 EDT 2005

OSTI ID:1175421

Bayley, Hagan P.; Howorka, Stefan G.; Movileanu, Liviu

Provided are pore-subunit polypeptides covalently linked to one or more sensing moieties, and uses of these modified polypeptides to detect and/or measure analytes or physical characteristics within a given sample.

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Research Organization:: Texas A And M University, College Station, TX (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: FG0397ER20271

Assignee:: Texas A And M University (College Station, TX)

Patent Number(s):: 6,916,665

Application Number:: 09/781,697

OSTI ID:: 1175421

Country of Publication:: United States

Language:: English

References (5)

Sensing proteins outside of the box van der Goot, F. Gisou; Matile, Stefan Nature Biotechnology, Vol. 18, Issue 10 https://doi.org/10.1038/80217	journal	October 2000
A Protein Pore with a Single Polymer Chain Tethered within the Lumen Howorka, Stefan; Movileanu, Liviu; Lu, Xiaofeng Journal of the American Chemical Society, Vol. 122, Issue 11 https://doi.org/10.1021/ja993221h	journal	March 2000
Calixarenes, Macrocycles with (Almost) Unlimited Possibilities Böhmer, Volker Angewandte Chemie International Edition in English, Vol. 34, Issue 7, p. 713-745 https://doi.org/10.1002/anie.199507131	journal	April 1995
Detecting protein analytes that modulate transmembrane movement of a polymer chain within a single protein pore Movileanu, Liviu; Howorka, Stefan; Braha, Orit Nature Biotechnology, Vol. 18, Issue 10 https://doi.org/10.1038/80295	journal	October 2000
The Gramicidin-Based Biosensor: A Functioning Nano-Machine Cornell, B. A.; Braach-Maksvytis, V. L. B.; King, L. G. Novartis Foundation Symposium 225 ‐ Gramicidin and Related Ion Channel‐Forming Peptides: Gramicidin and Related Ion Channel‐Forming Peptides: Novartis Foundation Symposium 225 https://doi.org/10.1002/9780470515716.ch15	book	September 2007

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