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Synthesis of 2'-deoxy-2'-[.sup.18F]fluoro-5-methyl-1-B-D-arabinofuranosyluracil (.sup.18F-FMAU)

Patent ·
OSTI ID:1165432
; ;
The present invention relates to methods of synthesizing .sup.18F-FMAU. In particular, .sup.18F-FMAU is synthesized using one-pot reaction conditions in the presence of Friedel-Crafts catalysts. The one-pot reaction conditions are incorporated into a fully automated cGMP-compliant radiosynthesis module, which results in a reduction in synthesis time and simplifies reaction conditions. The one-pot reaction conditions are also suitable for the production of 5-substituted thymidine or cytidine analogs. The products from the one-pot reaction (e.g. the labeled thymidine or cytidine analogs) can be used as probes for imaging tumor proliferative activity. More specifically, these [.sup.18F]-labeled thymidine or cytidine analogs can be used as a PET tracer for certain medical conditions, including, but not limited to, cancer disease, autoimmunity inflammation, and bone marrow transplant.
Research Organization:
University of Southern California, Los Angeles, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
SC0002353
Assignee:
University of Southern California (Los Angeles, CA)
Patent Number(s):
8,912,319
Application Number:
13/183,924
OSTI ID:
1165432
Country of Publication:
United States
Language:
English

References (11)

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journal January 2002
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