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Methods for separating medical isotopes using ionic liquids

Patent ·
OSTI ID:1160264

A method for extracting a radioisotope from an aqueous solution, the method comprising: a) intimately mixing a non-chelating ionic liquid with the aqueous solution to transfer at least a portion of said radioisotope to said non-chelating ionic liquid; and b) separating the non-chelating ionic liquid from the aqueous solution. In preferred embodiments, the method achieves an extraction efficiency of at least 80%, or a separation factor of at least 1.times.10.sup.4 when more than one radioisotope is included in the aqueous solution. In particular embodiments, the method is applied to the separation of medical isotopes pairs, such as Th from Ac (Th-229/Ac-225, Ac-227/Th-227), or Ra from Ac (Ac-225 and Ra-225, Ac-227 and Ra-223), or Ra from Th (Th-227 and Ra-223, Th-229 and Ra-225).

Research Organization:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC05-00OR22725
Assignee:
UT-Battelle, LLC (Oak Ridge, TN)
Patent Number(s):
8,865,094
Application Number:
13/614,757
OSTI ID:
1160264
Country of Publication:
United States
Language:
English

References (13)

Efficient removal of caesium ions from aqueous solution using a calix crown ether in ionic liquids: mechanism and radiation effect journal January 2010
Feasibility of Ionic Liquids as Alternative Separation Media for Industrial Solvent Extraction Processes journal June 2005
Bicyclic imidazolium-based ionic liquids: synthesis and characterization journal February 2007
Protic Ionic Liquids:  Properties and Applications journal January 2008
Lanthanides and Actinides in Ionic Liquids journal June 2007
Solvent Extraction of Sr 2+ and Cs + Based on Room-Temperature Ionic Liquids Containing Monoaza-Substituted Crown Ethers journal May 2004
Task-specific ionic liquids for the extraction of metal ions from aqueous solutions journal January 2001
An 225Ac/213Bi generator system for therapeutic clinical applications: construction and operation journal May 1999
Solvent extraction of strontium nitrate by a crown ether using room-temperature ionic liquids † journal January 1999
A Striking Effect of Ionic‐Liquid Anions in the Extraction of Sr 2+ and Cs + by Dicyclohexano‐18‐Crown‐6 journal March 2006
An Improved Generator for the Production of 213Bi from 225Ac journal January 1997
Optimizations of Radiolabeling of Immunoproteins with 213Bi journal January 1997
Ion-exchange as a mode of cation transfer into room-temperature ionic liquids containing crown ethers: implications for the ‘greenness’ of ionic liquids as diluents in liquid–liquid extraction journal October 2001

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