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Title: Unnatural reactive amino acid genetic code additions

Abstract

This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.

Inventors:
; ; ; ;
Publication Date:
Research Org.:
The Scripps Research Inst., La Jolla, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1151769
Patent Number(s):
8,815,542
Application Number:
13/787,400
Assignee:
The Scripps Research Institute (La Jolla, CA) OAK
DOE Contract Number:
FG03-00ER45812
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Deiters, Alexander, Cropp, T. Ashton, Chin, Jason W., Anderson, J. Christopher, and Schultz, Peter G. Unnatural reactive amino acid genetic code additions. United States: N. p., 2014. Web.
Deiters, Alexander, Cropp, T. Ashton, Chin, Jason W., Anderson, J. Christopher, & Schultz, Peter G. Unnatural reactive amino acid genetic code additions. United States.
Deiters, Alexander, Cropp, T. Ashton, Chin, Jason W., Anderson, J. Christopher, and Schultz, Peter G. Tue . "Unnatural reactive amino acid genetic code additions". United States. doi:. https://www.osti.gov/servlets/purl/1151769.
@article{osti_1151769,
title = {Unnatural reactive amino acid genetic code additions},
author = {Deiters, Alexander and Cropp, T. Ashton and Chin, Jason W. and Anderson, J. Christopher and Schultz, Peter G.},
abstractNote = {This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Aug 26 00:00:00 EDT 2014},
month = {Tue Aug 26 00:00:00 EDT 2014}
}

Patent:

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