Unnatural reactive amino acid genetic code additions

Deiters, Alexander; Cropp, T. Ashton; Chin, Jason W.; Anderson, Christopher J.; Schultz, Peter G.

Unnatural reactive amino acid genetic code additions

Patent · 25 October 2017

OSTI ID:1404921

Deiters, Alexander; Cropp, T. Ashton; Chin, Jason W.; Anderson, Christopher J.; Schultz, Peter G.

This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.

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Research Organization:: The Scripps Research Institute, La Jolla, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: FG03-00ER45812

Assignee:: The Scripps Research Institute

Patent Number(s):: 9,797,908

Application Number:: 14/338,113

OSTI ID:: 1404921

Country of Publication:: United States

Language:: English

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