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Detection of electrophilic and nucleophilic chemical agents

Patent ·
OSTI ID:1150085

A "real time" method for detecting chemical agents generally and particularly electrophilic and nucleophilic species by employing tunable, precursor sensor materials that mimic the physiological interaction of these agents to form highly florescent berberine-type alkaloids that can be easily and rapidly detected. These novel precursor sensor materials can be tuned for reaction with both electrophilic (chemical species, toxins) and nucleophilic (proteins and other biological molecules) species. By bonding or otherwise attaching these precursor molecules to a surface or substrate they can be used in numerous applications.

Research Organization:
SNL-A (Sandia National Laboratories, Albuquerque, NM (United States))
Sponsoring Organization:
USDOE
DOE Contract Number:
AC04-94AL85000
Assignee:
Sandia Corporation (Albuquerque, NM)
Patent Number(s):
8,802,444
Application Number:
13/553,959
OSTI ID:
1150085
Country of Publication:
United States
Language:
English

References (1)

Oxidation Reactions of 2′-Functionalized 3-Aryltetrahydro and 3,4-Dihydroisoquinolines journal November 1995

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