Regional assignment of the human DNA repair gene (XRCC4L) to the 5q13-q14 boundary by in situ hybridization
- Los Alamos National Lab., NM (United States); and others
Human chromosomes carrying genes that complement DNA repair deficiencies in rodent mutant cells have been identified using somatic cell genetic techniques. Recently, several ionizing radiation-sensitive rodent mutants have been isolated. Some of these mutants are deficient in the rejoining of radiation-induced DNA double-strand breaks. The hamster DNA DSB repair-deficient mutants have been assigned to at least three genetic complementation groups. However, the genetic relationship, if any, between the mouse and the hamster DNA DSB repair-deficient mutants has not been well established. The genes involved in radiation sensitivity have been designated human X-ray repair cross complementing genes (XRCC). One of the DNA DSB repair-deficient complementation groups, CHO mutant XR-1, has been well characterized, and the human gene that complements the radiation sensitivity of mutant XR-1 cells has been designated XRCC4. The mouse DNA DSB repair-deficient cell line, M10, may belong to the same complementation group as XR-1. Therefore, the human gene that complements the radiation sensitivity of mutant M10 cells has been designated XRCC4L. 7 refs., 1 fig.
- OSTI ID:
- 114909
- Journal Information:
- Genomics, Journal Name: Genomics Journal Issue: 1 Vol. 27; ISSN GNMCEP; ISSN 0888-7543
- Country of Publication:
- United States
- Language:
- English
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