Sheathless interface for coupling capillary electrophoresis with mass spectrometry

Wang, Chenchen; Tang, Keqi; Smith, Richard D.

Title: Sheathless interface for coupling capillary electrophoresis with mass spectrometry

Patent · Tue Jun 17 00:00:00 EDT 2014

OSTI ID:1134337

Wang, Chenchen; Tang, Keqi; Smith, Richard D.

A sheathless interface for coupling capillary electrophoresis (CE) with mass spectrometry is disclosed. The sheathless interface includes a separation capillary for performing CE separation and an emitter capillary for electrospray ionization. A portion of the emitter capillary is porous or, alternatively, is coated to form an electrically conductive surface. A section of the emitter capillary is disposed within the separation capillary, forming a joint. A metal tube, containing a conductive liquid, encloses the joint.

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Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC05-76RLO1830

Assignee:: Battelle Memorial Institute (Richland, WA)

Patent Number(s):: 8,754,370

Application Number:: 13/788,854

OSTI ID:: 1134337

Resource Relation:: Patent File Date: 2013 Mar 07

Country of Publication:: United States

Language:: English

References (15)

Capillary electrophoresis electrospray ionization mass spectrometry interface Smith, Richard D.; Severs, Joanne C. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5993633 US Patent Document 5,993,633	patent	November 1999
Contiguous capillary electrospray sources and analytical devices Janini, George; Issaq, Haleen J.; Veenstra, Timothy D. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20060057556 US Patent Application 10/529967; 20060057556	patent-application	March 2006
Capillary Emitter for Electrospray Mass Spectrometry Finch, Jeffrey W.; Granger, Jennifer H. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20070267293 US Patent Application 10/598799; 20070267293	patent-application	November 2007
Systems for Microchip Capillary Electrophoresis Absent Electrokinetic Injection Sun, Xuefei; Kelly, Ryan T.; Tang, Keqi https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20120318672 US Patent Application 13/596360; 20120318672	patent-application	December 2012
Microchips with Integrated Multiple Electrospray Ionization Emitters and Related Methods, Systems and Devices Ramsey, John Michael; Chambers, Andrew https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20130327936 US Patent Application 14/001549; 20130327936	patent-application	December 2013
Simplifying CE−MS Operation. 2. Interfacing Low-Flow Separation Techniques to Mass Spectrometry Using a Porous Tip Moini, Mehdi Analytical Chemistry, Vol. 79, Issue 11 https://doi.org/10.1021/ac0704560	journal	June 2007
Modified liquid junction interface for nonaqueous capillary electrophoresis-mass spectrometry Jussila, Matti; Sinervo, Kai; Porras, Simo P. Electrophoresis, Vol. 21, Issue 15, p. 3311-3317 https://doi.org/10.1002/1522-2683(20000901)21:15<3311::AID-ELPS3311>3.0.CO;2-N	journal	September 2000
Capillary Electrophoresis to Mass Spectrometry Interface Using a Porous Junction Whitt, Jacob T.; Moini, Mehdi Analytical Chemistry, Vol. 75, Issue 9 https://doi.org/10.1021/ac026380j	journal	May 2003
Capillary electrophoresis–electrospray ionization-mass spectrometry interfaces: Fundamental concepts and technical developments Bonvin, Grégoire; Schappler, Julie; Rudaz, Serge Journal of Chromatography A, Vol. 1267, p. 17-31 https://doi.org/10.1016/j.chroma.2012.07.019	journal	December 2012
Capillary Isotachophoresis-Nanoelectrospray Ionization-Selected Reaction Monitoring MS via a Novel Sheathless Interface for High Sensitivity Sample Quantification Wang, Chenchen; Lee, Cheng S.; Smith, Richard D. Analytical Chemistry, Vol. 85, Issue 15 https://doi.org/10.1021/ac401202c	journal	July 2013
Selective enrichment and ultrasensitive identification of trace peptides in proteome analysis using transient capillary isotachophoresis/zone electrophoresis coupled with nano-ESI-MS An, Yanming; Cooper, Jonathan W.; Balgley, Brian M. ELECTROPHORESIS, Vol. 27, Issue 18 https://doi.org/10.1002/elps.200600093	journal	September 2006
Application of capillary isotachophoresis-based multidimensional separations coupled with electrospray ionization-tandem mass spectrometry for characterization of mouse brain mitochondrial proteome Fang, Xueping; Wang, Weijie; Yang, Li ELECTROPHORESIS, Vol. 29, Issue 10 https://doi.org/10.1002/elps.200700609	journal	May 2008
Isotachophoresis as an on-line concentration pretreatment technique in capillary electrophoresis Stegehuis, D. S.; Irthu, H.; Tjaden, U. R. Journal of Chromatography A, Vol. 538, Issue 2, p. 393-402 https://doi.org/10.1016/S0021-9673(01)88860-9	journal	January 1991
Ultrasensitive Sample Quantitation via Selected Reaction Monitoring Using CITP/CZE–ESI-Triple Quadrupole MS Wang, Chenchen; Lee, Cheng S.; Smith, Richard D. Analytical Chemistry, Vol. 84, Issue 23 https://doi.org/10.1021/ac302616m	journal	November 2012
Characterization of the Microdialysis Junction Interface for Capillary Electrophoresis/Microelectrospray Ionization Mass Spectrometry Severs, Joanne C.; Smith, Richard D. Analytical Chemistry, Vol. 69, Issue 11 https://doi.org/10.1021/ac9611226	journal	June 1997

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