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Compositions of orthogonal lysyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof

Patent ·
OSTI ID:1126706
; ; ;

Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal lysyl-tRNAs, orthogonal lysyl-aminoacyl-tRNA synthetases, and orthogonal pairs of lysyl-tRNAs/synthetases, which incorporate homoglutamines into proteins are provided in response to a four base codon. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with homoglutamines using these orthogonal pairs.

Research Organization:
The Scripps Research Institute, La Jolla, CA, USA
Sponsoring Organization:
USDOE
Assignee:
The Scripps Research Institute (La Jolla, CA)
Patent Number(s):
8,669,073
Application Number:
13/246,490
OSTI ID:
1126706
Country of Publication:
United States
Language:
English

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