Transformation of gram positive bacteria by sonoporation

Yang, Yunfeng; Li, Yongchao

Transformation of gram positive bacteria by sonoporation

Patent · 11 March 2014

OSTI ID:1126704

Yang, Yunfeng; Li, Yongchao

The present invention provides a sonoporation-based method that can be universally applied for delivery of compounds into Gram positive bacteria. Gram positive bacteria which can be transformed by sonoporation include, for example, Bacillus, Streptococcus, Acetobacterium, and Clostridium. Compounds which can be delivered into Gram positive bacteria via sonoporation include nucleic acids (DNA or RNA), proteins, lipids, carbohydrates, viruses, small organic and inorganic molecules, and nano-particles.

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Research Organization:: ORNL (Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States))

Sponsoring Organization:: USDOE

Assignee:: UT-Battelle, LLC (Oak Ridge, TN)

Patent Number(s):: 8,669,085

Application Number:: 12/657,885

OSTI ID:: 1126704

Country of Publication:: United States

Language:: English

References (25)

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