Boron neutron capture therapy for oral precancer: proof of principle in an experimental animal model

Journal Article · Fri Nov 01 00:00:00 EDT 2013 · Oral Diseases

DOI:https://doi.org/10.1111/odi.12077· OSTI ID:1120804

Hughes, A. Monti; Pozzi, ECC; Thorp, S.; Garabalino, M. A.; Farias, R. O.; Gonzalez, S. J.; Heber, E. M.; Itoiz, M. E.; Aromando, R. F.; Molinari, A. J.; Miller, M.; Nigg, D. W.; Curotto, P.; Trivillin, V. A.; Schwint, A. E.

Field-cancerized tissue can give rise to second primary tumours, causing therapeutic failure. Boron neutron capture therapy (BNCT) is based on biological targeting and would serve to treat undetectable foci of malignant transformation. The aim of this study was to optimize BNCT for the integral treatment for oral cancer, with particular emphasis on the inhibitory effect on tumour development originating in precancerous conditions, and radiotoxicity of different BNCT protocols in a hamster cheek pouch oral precancer model.

• Research Organization: Idaho National Lab. (INL), Idaho Falls, ID (United States)
• Sponsoring Organization: USDOE
• DOE Contract Number: DE-AC07-05ID14517
• OSTI ID: 1120804
• Report Number(s): INL/JOU-14-31284
• Journal Information: Oral Diseases, Vol. 19, Issue 8; ISSN 1354-523X
• Country of Publication: United States
• Language: English

Related Subjects

99 GENERAL AND MISCELLANEOUS
boron neutron capture therapy
field cancerization
hamster cheek pouch oral precancer model
oral cancer
precancerous conditions