Tumor blood vessel "normalization" improves the therapeutic efficacy of boron neutron capture therapy (BNCT) in experimental oral cancer
Journal Article
·
· Radiation Research
OSTI ID:1035913
We previously demonstrated the efficacy of BNCT mediated by boronophenylalanine (BPA) to treat tumors in a hamster cheek pouch model of oral cancer with no normal tissue radiotoxicity and moderate, albeit reversible, mucositis in precancerous tissue around treated tumors. It is known that boron targeting of the largest possible proportion of tumor cells contributes to the success of BNCT and that tumor blood vessel normalization improves drug delivery to the tumor. Within this context, the aim of the present study was to evaluate the effect of blood vessel normalization on the therapeutic efficacy and potential radiotoxicity of BNCT in the hamster cheek pouch model of oral cancer.
- Research Organization:
- Idaho National Laboratory (INL)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC07-05ID14517
- OSTI ID:
- 1035913
- Report Number(s):
- INL/JOU-12-25008
- Journal Information:
- Radiation Research, Journal Name: Radiation Research Journal Issue: 1 Vol. 177; ISSN 0033-7587; ISSN RAREAE
- Country of Publication:
- United States
- Language:
- English
Similar Records
“Sequential” Boron Neutron Capture Therapy (BNCT): A Novel Approach to BNCT for the Treatment of Oral Cancer in the Hamster Cheek Pouch Model
Boron biodistribution for BNCT in the hamster cheek pouch oral cancer model: Combined administration of BSH and BPA
Boron Neutron Capture Therapty (BNCT) in an Oral Precancer Model: Therapeutic Benefits and Potential Toxicity of a Double Application of BNCT with a Six-Week Interval
Journal Article
·
Fri Apr 01 00:00:00 EDT 2011
· Radiation Research
·
OSTI ID:1013366
Boron biodistribution for BNCT in the hamster cheek pouch oral cancer model: Combined administration of BSH and BPA
Journal Article
·
Sun Jun 01 00:00:00 EDT 2014
· Applied Radiation and Isotopes
·
OSTI ID:1156921
Boron Neutron Capture Therapty (BNCT) in an Oral Precancer Model: Therapeutic Benefits and Potential Toxicity of a Double Application of BNCT with a Six-Week Interval
Journal Article
·
Tue Nov 01 00:00:00 EDT 2011
· Oral Oncology
·
OSTI ID:1033262